Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
about
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsNeurodegeneration in Alzheimer's disease: caspases and synaptic element interdependenceIron and neurodegeneration: from cellular homeostasis to diseaseAPP binds DR6 to trigger axon pruning and neuron death via distinct caspasesThe importance of integrating basic and clinical research toward the development of new therapies for Huntington diseasepARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingThe DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptidesThe enigma of caspase-2: the laymen's viewPathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1The P42 peptide and Peptide-based therapies for Huntington's diseaseCell biology of spinocerebellar ataxiaTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyFibrillogenesis of huntingtin and other glutamine containing proteinsMouse models of polyglutamine diseases: review and data table. Part IMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseA Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's diseaseMutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 miceN17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceHigh-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease modelImpaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.The crystal structure of caspase-6, a selective effector of axonal degenerationSubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical AssaysPhosphorylation regulates assembly of the caspase-6 substrate-binding groove.Allosteric peptides bind a caspase zymogen and mediate caspase tetramerizationCell death in the nervous systemOpposing effects of polyglutamine expansion on native protein complexes contribute to SCA1RNA toxicity is a component of ataxin-3 degeneration in DrosophilaLithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CSIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivoMutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathwayExpression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liverThe caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionPartial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesisTargeting several CAG expansion diseases by a single antisense oligonucleotideA quantitative method for the specific assessment of caspase-6 activity in cell cultureSerine 421 regulates mutant huntingtin toxicity and clearance in mice.
P2860
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P2860
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@en
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@nl
type
label
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@en
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@nl
prefLabel
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@en
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@nl
P2093
P50
P1433
P1476
Cleavage at the caspase-6 site ...... tion due to mutant huntingtin.
@en
P2093
Brendan Haigh
Cheryl L Wellington
Crystal N Doty
Donald W Nicholson
Elizabeth J Slow
Jacqueline Pearson
Jacqueline Shehadeh
Lisa Bertram
Nagat Bissada
P304
P356
10.1016/J.CELL.2006.04.026
P407
P577
2006-06-01T00:00:00Z