Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
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Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signalingThe importance of integrating basic and clinical research toward the development of new therapies for Huntington diseaseEarly alterations of brain cellular energy homeostasis in Huntington disease modelsMitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cellsSPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasisMultiple Aspects of Gene Dysregulation in Huntington's DiseaseMitochondria, calcium and cell death: a deadly triad in neurodegenerationExendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's diseaseSCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysisThe association between PGC-1α and Alzheimer's diseaseThe P42 peptide and Peptide-based therapies for Huntington's diseaseSirt1 and the MitochondriaOld Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative DisordersElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsThe many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapyTransglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS blockParkinson's disease, insulin resistance and novel agents of neuroprotectionThe dynamics of the mitochondrial organelle as a potential therapeutic targetMitophagy: mechanisms, pathophysiological roles, and analysisNew insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyondPGC-1α, mitochondrial dysfunction, and Huntington's diseaseMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Neuroinflammation in overnutrition-induced diseasesTherapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseNovel mitochondrial targets for neuroprotectionHuntington's disease: underlying molecular mechanisms and emerging conceptsTranscriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisAfter the banquet: mitochondrial biogenesis, mitophagy, and cell survivalInduction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in MiceReinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtinAmitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.Thiazolidinediones promote axonal growth through the activation of the JNK pathwayHuntingtin's function in axonal transport is conserved in Drosophila melanogasterMaintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunctionThe critical roles of mitophagy in cerebral ischemiaThe protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathwayMitochondrial fragmentation in neurodegenerationCREB and cAMP response element-mediated gene expression in the ischemic brain
P2860
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P2860
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Transcriptional repression of ...... unction and neurodegeneration.
@en
Transcriptional repression of ...... unction and neurodegeneration.
@nl
type
label
Transcriptional repression of ...... unction and neurodegeneration.
@en
Transcriptional repression of ...... unction and neurodegeneration.
@nl
prefLabel
Transcriptional repression of ...... unction and neurodegeneration.
@en
Transcriptional repression of ...... unction and neurodegeneration.
@nl
P2093
P1433
P1476
Transcriptional repression of ...... function and neurodegeneration
@en
P2093
Christopher N Parkhurst
Dimitri Krainc
Fran Borovecki
Hyunkyung Jeong
P356
10.1016/J.CELL.2006.09.015
P407
P50
P577
2006-10-01T00:00:00Z