Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.
about
Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's DiseaseThe choreography of neuroinflammation in Huntington's diseaseKynurenines in the mammalian brain: when physiology meets pathologyStructural basis of kynurenine 3-monooxygenase inhibitionThe kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's diseaseTargeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAINModeling Huntington disease in yeast: perspectives and future directions.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspectiveActivated microglia proliferate at neurites of mutant huntingtin-expressing neuronsAn exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.The role of the immune system in triplet repeat expansion diseasesTryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.Polyglutamine (polyQ) disorders: the chromatin connection.Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease.Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.Epigenetics and the modulation of neuroinflammation.Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegenerationOf mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Involvement of kynurenines in Huntington's disease and stroke-induced brain damage.Contribution of yeast models to neurodegeneration research.An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicityMitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration.The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.Glial epigenetics in neuroinflammation and neurodegeneration.Microglia and inflammation: conspiracy, controversy or control?The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).The emerging field of epigenetics in neurodegeneration and neuroprotection.On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo.Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.Effects of mitochondrial dysfunction on the immunological properties of microgliaComparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
P2860
Q26781849-FF64B0FC-C7BD-4720-82D7-86BCF8F27698Q26828403-6FFBA8F6-CF04-48A4-B579-5BE9D3D83341Q27003296-71B05C23-DC4F-4FDD-ABF4-6EA697764347Q27677296-7D28653C-591E-4BBB-BFA4-AC596E18500EQ28239367-051C8763-330B-4CE7-B482-D5EF1ADA1FC1Q29306917-32FD078B-C717-4BF1-BDE5-2EAF169A982AQ33575494-451D71C7-F38A-403F-AE61-B602B106D657Q35024695-680B8128-9DF7-4ACC-8456-9AEA538BB4E9Q35103285-725DA1C9-0623-4394-87AA-0ADF163A8E5FQ35135962-7A0BBE80-4C02-47D5-B37D-241A255EC87BQ35271805-27EACB62-7215-4B66-BDB6-CF319F8B04CFQ35366778-D78EF0F4-F5AD-4628-A07A-7981734BDEABQ35775787-1D7134A2-ECAF-46F1-9850-74541E630F3FQ36328114-7EBEE329-415C-4BA5-A248-81E7B8FA05B3Q36608360-E5552AA8-7DB8-430A-8483-4A44BB862A8AQ37013795-F4B95776-8E20-4382-B79B-C14C94C9CA79Q37040974-AB6C4A89-FF7F-4C49-A97F-35D8A45FA6FDQ37249157-A82DB67B-EB9B-4063-AF67-F595B0F6A6E8Q37270004-0BD87B8B-3603-42AD-9C23-F638BD033BBCQ37460122-2D64B879-9CDD-47FA-A20D-8D521845AEE4Q37603963-A3EC6C45-352D-429B-B0B6-D91EFADEBD00Q37623378-EC3915CC-0D90-469F-B349-86B55A314376Q37776087-9FE1D115-C06A-4F95-8FD2-6EF7B96D94D8Q37892975-3705A658-71E8-4161-8DA4-E32850B8F352Q38036519-0D74DCBC-F273-4EA6-8F84-53D87E3F9509Q38038981-7C194D29-CFA4-4417-9FF1-A31F4951E470Q38066197-6B8B9AEA-5D62-4EBC-B482-DAF0F15351D2Q38103448-D9301EDE-C575-4344-9FBF-4BEAB54C01ECQ38197952-79A8A978-F815-4CB1-B821-8A22008EE833Q38227727-C348094F-A134-4719-A464-1D7D1C1F2201Q38253558-E70EB629-19D9-4E1E-92B4-7CB0BF7851EAQ38393072-864DE223-1E78-4F1B-9463-3E6D05BF35D4Q38996403-3D279F0B-1F9E-4CA7-BAC1-F9B6392FEFA3Q39149450-508A4B75-0156-45A2-9864-3E31F661ED10Q39313679-CE37F4DD-1185-4F20-A016-0333A66C48B4Q41139088-0271EB79-3D18-4802-895C-FF7C5F3C9EF9Q41557401-77234449-E1C9-41DE-8C56-27677FD4864EQ42528510-5D95DE86-4866-4665-BD77-98100B112117Q55498681-9C563E6C-532C-4B92-B4D7-DDDF13FDFCB4
P2860
Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@en
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@nl
type
label
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@en
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@nl
prefLabel
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@en
Histone deacetylase inhibition ...... a mutant huntingtin fragment.
@nl
P2093
P2860
P356
P1476
Histone deacetylase inhibition ...... g a mutant huntingtin fragment
@en
P2093
Christine S Cheah
Daniel Zwilling
Flaviano Giorgini
Jennifer L Wacker
Li-Chun L Tsai
Paolo Guidetti
Paul J Muchowski
Robert Schwarcz
Thomas Möller
Wanda Kwan
P2860
P304
P356
10.1074/JBC.M708192200
P407
P50
P577
2007-12-13T00:00:00Z