about
PIAS4 SUMOylates MDC1RNF4 ubiquitinates MDC1SIRT6 deacetylates RBBP8MRN complex binds CDK2 and RBBP8CDK2 phosphorylates RBBP8ATM phosphorylates RBBP8BRCA1 binds phosphorylated RBBP8Initial resection of double-strand break endsEXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitmentLong-range resection of DNA DSBs by EXO1 or DNA2Association of RPA complexes with ssDNA at resected DNA DSBsBinding of ATR:ATRIP to RPA at resected DNA DSBsATR activation at DNA DSBsATR phosphorylates RPA2CHEK1 is recruited to resected DNA DSBsActivation of CHEK1 at resected DNA DSBsPPP4C:PPP4R2 dephosphorylates RPA2
P361
Q50287342-29A256EB-A7D9-4C8D-8B1F-2AB4652B5A63Q50287343-42E90E0F-E7B2-41D2-B313-67BDB662D44EQ50287344-16B6E0FB-6D40-4F71-BB30-82E275834394Q50287345-6A57EA24-0800-435C-99D6-8798551CD0A8Q50287346-5E4A01E8-A039-4FD6-9797-4A35DEAAEFA4Q50287347-F832750A-5FBC-4E51-895D-2C7E0D5347DAQ50287348-BA5368F2-0701-4370-B07D-0DE6798B3B9CQ50287349-2A0A8F00-FD7C-40B2-8B24-0A368D2D79A8Q50287350-C8FACA93-968D-4D8D-8FB5-CB0AFB27A861Q50287351-A7A32012-D8F3-4E43-A90B-7A615D143233Q50287353-6ECF4D9B-DEF6-44FA-894C-9B1CEC208347Q50287354-26B40AB5-1E16-4FE5-9530-7DFFEAA6B304Q50287355-9A81B0B8-FD07-4669-8AB4-4793F7B56ECDQ50287356-4B925717-4165-4C0C-9023-4749797D0056Q50287357-89A24CD8-2C38-494F-9F97-F54AAB63D962Q50287358-976B0B47-62DE-46A6-B11A-1610E51C24B6Q50287359-26CD8FFC-A96C-4499-BB8C-59B5E3E01F1D
P361
description
An instance of the biological ...... and break ends in Homo sapiens
@en
name
Processing of DNA double-strand break ends
@en
type
label
Processing of DNA double-strand break ends
@en
prefLabel
Processing of DNA double-strand break ends
@en
P2860
P527
P2860
P3937
R-HSA-5693607