about
PRKCB (Protein kinase C beta; PKC-beta) binds diacylglycerol and phosphatidylserinePRKCB (PKC-beta) phosphorylates CARMA1CARMA1 recruits MALT1 and BCL10 forming CBM ComplexCARMA1:BCL10:MALT1 complex recruits TAK1 and IKKTAK1 associated with the CBM complex phosphorylates IKKbetaActivated IKK phosphorylates I-kappaBSCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkBSCF-beta-TrCP ubiquitinylates IkBUbiquitinated IkB is degradedNF-kappaB translocates from the cytosol to the nucleus
P361
Q50291487-A0D09056-2734-421C-9495-708124081AA8Q50291488-087B8195-FEF1-4D1B-A9CA-5274B9938AEBQ50291489-0AABA317-76A2-431C-BEB1-97ADF44B6AC7Q50291491-9FE0A9D3-9F8D-4A15-8F18-154EE00168CEQ50291493-11942B31-B55F-4E81-9A14-7FA688B46074Q50291494-69014798-180C-4758-A897-3B891DEF520DQ50291496-83A1A852-2CCF-41EF-AEF5-6A1175C75130Q50291497-AA805FED-C554-48D2-B083-547FFDA7423BQ50291498-7528E241-6736-433A-B644-7DFC050E6083Q50291500-6639BD10-EFD7-4846-8870-9D2A821C3798
P361
description
An instance of the biological pathway Activation of NF-kappaB in B cells in Homo sapiens
@en
name
Activation of NF-kappaB in B cells
@en
type
label
Activation of NF-kappaB in B cells
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prefLabel
Activation of NF-kappaB in B cells
@en
P2860
P527
P2860
P3937
R-HSA-1169091