Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. - Wikidata - awgldk - TriplyDB

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

http://www.wikidata.org/entity/Q45345853

about

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis Critical role for mouse marginal zone B cells in PF4/heparin antibody production.Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.Immunologic applications of conditional gene modification technology in the mouse Rescue of notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancer c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.A central role for Notch in effector CD8(+) T cell differentiation Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.An overview of notch signaling in adult tissue renewal and maintenance.Notch regulates cytolytic effector function in CD8+ T cells.Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response.Cross-differentiation from the CD8 lineage to CD4 T cells in the gut-associated microenvironment with a nonessential role of microbiota Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.Tissue adaptation of regulatory and intraepithelial CD4⁺ T cells controls gut inflammation.Notch system in the linkage of innate and adaptive immunity.CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice.T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.The molecular signature of CD8+ T cells undergoing deletional tolerance Transmission of survival signals through Delta-like 1 on activated CD4(+) T cells.Notch Signaling Contributes to Liver Inflammation by Regulation of Interleukin-22-Producing Cells in Hepatitis B Virus Infection.Survival of mature T cells depends on signaling through HOIP.Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation.TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections Diversity in CD8(+) T cell differentiation.Notch signaling in the hematopoietic system.Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells.Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation.CD8(+) T cells: foot soldiers of the immune system Notch and inflammatory T-cell response: new developments and challenges.Genetic and Epigenetic Regulation of PD-1 Expression

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Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

http://www.wikidata.org/entity/Q45345853

description

2008 nî lūn-bûn

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Notch2 integrates signaling by ...... o promote T cell cytotoxicity.

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Notch2 integrates signaling by ...... o promote T cell cytotoxicity.

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Nature Immunology

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Notch2 integrates signaling by ...... to promote T cell cytotoxicity

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Akiko Kitamura

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Chieko Ishifune

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Hidefumi Kojima

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Hideo Yagita

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Ichiro Taniuchi

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Mamiko Sakata-Yanagimoto

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Saburo Sone

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Shigeru Chiba

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Takeshi Kurihara

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Yoshiaki Minato

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P2860

Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms

p300 acts as a transcriptional coactivator for mammalian Notch-1

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

CREB--a real culprit in oncogenesis

Control of effector CD8+ T cell function by the transcription factor Eomesodermin

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

Notch signalling: a simple pathway becomes complex

Central memory and effector memory T cell subsets: function, generation, and maintenance

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals

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1140-1147

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10.1038/NI.1649

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10

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9

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23191154

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18724371

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