Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro.
about
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cellsDNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy studyHIV-1 integrase crosslinked oligomers are active in vitroRole of Zn2+ ions in host-virus interactionsContribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear importMultifunctional facets of retrovirus integraseStructural basis for functional tetramerization of lentiviral integraseBinding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activityStructure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitorHIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsHIV-1 integrase catalytic core: molecular dynamics and simulated fluorescence decays.A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replicationSubstrate recognition and motion mode analyses of PFV integrase in complex with viral DNA via coarse-grained modelsRetroviral DNA IntegrationStructural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase.Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysisStructural determinants of metal-induced conformational changes in HIV-1 integrase.Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingAn inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase.Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation.Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integrationEfficiency and fidelity of full-site integration reactions using recombinant simian immunodeficiency virus integraseA large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.Molecular dynamics studies on the HIV-1 integrase catalytic domain.Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistanceA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.In search of authentic inhibitors of HIV-1 integration.Allosteric inhibitor development targeting HIV-1 integrase.Targeting HIV-1 integrase.HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infected patients failing a raltegravir-containing regimen.Lipid Peroxidation Correlates with HIVmRNA in Serodiscordant Heterosexual HIVpartners of Nigerian Origin.The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration.Role of host-encoded proteins in restriction of retroviral integration.Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription.Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.
P2860
Q24304259-58AC0FCE-8AD4-4B67-9ECF-1FEDE4471697Q24555222-C33DF1B5-1FF8-4F1D-B926-417934C9ABDFQ24556625-96C546FC-674A-4A38-90A9-E8991BB382DEQ24656940-48283BE9-88C6-474A-BEC6-D93FA6DB1AD3Q24814060-10AD24A8-2EFF-4868-B058-82EC096F0C61Q26795766-C2B2E07A-1B42-4434-8ACF-6D5EECDCFB8FQ27316560-CEF107BB-07C0-43E9-8EEE-5F9E94382A81Q27740341-90700CE5-7CD1-47D5-8AFB-4E951DAB85C9Q27749615-6DFA1642-8CC2-42B3-9031-AE1F45B2B708Q28212168-D7D8C407-8EBE-45FB-807B-A2EBD0DA25F8Q28367702-ED086975-18BF-4FC4-B5C7-18468AFB9E1EQ28483813-D224110D-EF64-403E-B6FE-CA41E958208BQ28485284-B0619AC5-7DB1-4D92-AFCA-2BE1F7F31F97Q28596842-4C853F5E-7A9C-4AB7-B4F5-04EAC0F006DDQ30009248-9909A2A2-D721-4152-80FC-4CA13B73FD26Q30157084-14420BCE-B4A3-4B5A-A02F-3FB89780DFABQ30175843-B5C7A386-B4F9-4239-85E3-F7F47524DB42Q30175939-02CB0D4D-81E9-4EB0-822D-71098625853BQ30341397-E8A1292C-00D4-42A1-BE36-5E217D11E86FQ30500118-67296C60-94C7-4E37-B0D4-351695C143BAQ30915736-416B7E8A-71F9-41E4-93CF-E6BF4F9FAB9EQ31035885-9DBBB13A-139B-42D9-8101-6CE3F1E675ACQ33780519-E50A64F3-A2A6-4BD9-BE75-175780BC84AAQ33812392-FAD83EA5-F4C1-45CC-A214-2E23E97E69E6Q33819179-E69453D9-1A31-4CC6-9A53-AFC2934F74EDQ33887922-37961783-FFF8-4028-B24D-900720805652Q33922412-07B685D2-C257-4B5D-9657-2DBC6339AA7AQ34161123-C3917283-C36A-453C-AFBF-C77BA7CC79C4Q34170581-B5534267-CD88-40B7-AA90-E39717D3784FQ34180538-151E0416-25DB-45B2-AA0F-4F13B5819693Q34249167-0560FF42-087E-440F-872E-964DF685E060Q34785977-985AAB72-2D3F-4DFA-B0E5-825759D91C87Q35046515-2C6BE693-B9C8-4E17-A4A1-B56D6723BAB3Q35050390-DA9AECE5-3459-4262-86C2-FD7DF49EDEDAQ35134947-EF5D304B-BCB8-469F-BF8B-82047CA9864BQ35184285-1CD049DF-81B1-40BC-935D-77F31AF771D9Q35538363-A9AB3B2D-2F4D-4126-99BC-F0AF7F88A2B3Q36052679-7DEB690E-45DE-4C37-BFDD-59251529D23DQ36098878-E6B00312-950E-4D50-A396-270B4D4AE0F6Q36538644-45384582-3005-4980-8B6E-2514D63197EC
P2860
Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@en
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@nl
type
label
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@en
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@nl
prefLabel
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@en
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@nl
P2093
P356
P1433
P1476
Zn2+ promotes the self-associa ...... rus type-1 integrase in vitro.
@en
P2093
P304
P356
10.1021/BI961849O
P407
P577
1997-01-01T00:00:00Z