about
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic miceTherapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patientsIdentification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutationsReactivation of developmentally silenced globin genes by forced chromatin looping.Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients.Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemiaA validated cellular biobank for β-thalassemia.Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.Gene therapy in thalassemia and hemoglobinopathies.Recent trends in the gene therapy of β-thalassemia.Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles.Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.A preclinical approach for gene therapy of beta-thalassemia.A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations.Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia.Complexation to Cationic Microspheres of Double-Stranded Peptide Nucleic Acid-DNA Chimeras Exhibiting Decoy ActivitymRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models
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description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Laura Breda
@ast
Laura Breda
@en
Laura Breda
@es
Laura Breda
@nl
Laura Breda
@sl
type
label
Laura Breda
@ast
Laura Breda
@en
Laura Breda
@es
Laura Breda
@nl
Laura Breda
@sl
altLabel
Breda L
@en
prefLabel
Laura Breda
@ast
Laura Breda
@en
Laura Breda
@es
Laura Breda
@nl
Laura Breda
@sl
P1053
T-3997-2017
P106
P21
P31
P3829
P4012
P496
0000-0003-2133-4432