Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.
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Oligonucleotide therapeutic approaches for Huntington diseaseHuntingtin's function in axonal transport is conserved in Drosophila melanogasterSpatial and temporal characteristics of normal and perturbed vesicle transportHuntingtin mediates dendritic transport of β-actin mRNA in rat neuronsThe regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Axonal transport and neurodegenerative disease: can we see the elephant?The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathwayHuntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouseStriatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Amyloid precursor protein is trafficked and secreted via synaptic vesiclesDifferential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Axonal transport plays a crucial role in mediating the axon-protective effects of NmNATRetrograde axonal transport: pathways to cell death?BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 miceNeuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouseMesenchymal stem cells for the treatment of neurodegenerative disease.Axonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingHigh throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.Computational analysis of axonal transport: a novel assessment of neurotoxicity, neuronal development and functionsOxidative stress inhibits axonal transport: implications for neurodegenerative diseases.Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice.β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin.Axonal transport defects in neurodegenerative diseases.Basic mechanisms of neurodegeneration: a critical update.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Brain networks in Huntington disease.The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathologyGelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.Integrated regulation of motor-driven organelle transport by scaffolding proteins.The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium.Regulation of dynein-dynactin-driven vesicular transport.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons.
P2860
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P2860
Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@en
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@nl
type
label
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@en
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@nl
prefLabel
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@en
Enhanced sensitivity of striat ...... induced by mutant huntingtin.
@nl
P1476
Enhanced sensitivity of striat ...... s induced by mutant huntingtin
@en
P2093
Lawrence S B Goldstein
Lu-Shiun Her
P304
13662-13672
P356
10.1523/JNEUROSCI.4144-08.2008
P407
P577
2008-12-01T00:00:00Z