Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study.
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Ubiquitous amyloidsDimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics studyStructural Conversion of Aβ17-42 Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic PathwaysMapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerizationModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsDesign and Characterization of Chemically Stabilized Aβ42 Oligomersβ-sheet propensity controls the kinetic pathways and morphologies of seeded peptide aggregation.Effects of surface interactions on peptide aggregate morphology.Stability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations.Analysis of the stabilities of hexameric amyloid-β(1-42) models using discrete molecular dynamics simulationsStructural basis of β-amyloid-dependent synaptic dysfunctions.Structural and fluctuational difference between two ends of Aβ amyloid fibril: MD simulations predict only one end has open conformations.Flexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Globular state in the oligomers formed by Abeta peptides.Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity.Mapping conformational ensembles of aβ oligomers in molecular dynamics simulationsAmyloid peptide Aβ40 inhibits aggregation of Aβ42: evidence from molecular dynamics simulations.Impact of sequence on the molecular assembly of short amyloid peptides.Nonsteroidal anti-inflammatory drug naproxen destabilizes Aβ amyloid fibrils: a molecular dynamics investigation.Binding of nonsteroidal anti-inflammatory drugs to Abeta fibrilCrucial role of nonspecific interactions in amyloid nucleation.Naproxen interferes with the assembly of Aβ oligomers implicated in Alzheimer's disease.Molecular origin of Gerstmann-Sträussler-Scheinker syndrome: insight from computer simulation of an amyloidogenic prion peptide.Minimal model of self-assembly: emergence of diversity and complexity.Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.Does amino acid sequence determine the properties of Aβ dimer?The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systemsStructural transitions and oligomerization along polyalanine fibril formation pathways from computer simulationsDynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein.Folding of pig gastric mucin non-glycosylated domains: a discrete molecular dynamics study.Influence of temperature on formation of perfect tau fragment fibrils using PRIME20/DMD simulationsStabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation InhibitionProtective V127 prion variant prevents prion disease by interrupting the formation of dimer and fibril from molecular dynamics simulations.SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AβPP/PS-1 transgenic mouse brain.Discrete molecular dynamics study of oligomer formation by N-terminally truncated amyloid β-protein.Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization.Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation.Polymorphism of fibrillar structures depending on the size of assembled Aβ17-42 peptides.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease
P2860
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P2860
Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@en
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@nl
type
label
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@en
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@nl
prefLabel
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@en
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@nl
P2093
P2860
P356
P1476
Elucidation of amyloid beta-pr ...... rete molecular dynamics study.
@en
P2093
P2860
P304
P356
10.1021/JA9096303
P407
P577
2010-03-01T00:00:00Z