Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. - Wikidata - awgldk - TriplyDB

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

http://www.wikidata.org/entity/Q45993868

about

Alzheimer mechanisms and therapeutic strategies Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model Impact of apolipoprotein E on Alzheimer's disease Genes associated with Alzheimer's disease: an overview and current status Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease Insulin: an emerging treatment for Alzheimer's disease dementia?Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases Genetic variants associated with neurodegenerative Alzheimer disease in natural models ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes In vivo human apolipoprotein E isoform fractional turnover rates in the CNS The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death.Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Accumulation of intraneuronal Abeta correlates with ApoE4 genotype Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier.Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.The role of apolipoprotein E in Alzheimer's disease.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction Transgenic animal models of neurodegeneration based on human genetic studies.Function and comorbidities of apolipoprotein e in Alzheimer's disease.Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice Human apoE isoforms differentially regulate brain amyloid-β peptide clearance Introducing Human APOE into Aβ Transgenic Mouse Models.Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

P2860

Q22252311-3CCE96CB-ED0A-46B6-8E3D-3E930C065FBF Q24338827-85EBF4C0-2032-4474-B7FC-FC0722ACC115 Q24567759-8AE966A4-8C41-4E18-9A2A-F9909BEC429B Q26747803-4F38F788-7BF3-4F97-9AAF-0D65758CF527 Q26822534-0C6546D9-4563-41E7-91B0-BE5760C6B3D7 Q26827376-67A63DA0-F815-4EA4-9ADA-07F38CE8D266 Q27009984-1A86219F-3025-44A5-B5A9-F8ABB097D403 Q28079843-DB1B77BF-E6CA-487D-9F4D-C583B9FBEC67 Q28081654-BF8DDF48-82B3-4BA5-BC30-859D69983C95 Q28282855-8EF55D1D-0E0A-488A-A0A7-45596AD9216C Q28553918-0432D486-5E51-41D4-8606-1AACE7C6A57A Q28728902-0BEECFFB-818B-4579-9D1F-B75A2F588323 Q28742884-8C546732-F681-4CE9-99D2-38DC4D6A816C Q30566020-5071D729-EED9-4018-8F30-7ABB4CC6E76F Q33112703-E9DF52EE-8FC9-4670-8A08-51B5F7870F23 Q33646882-7CD3CE22-E210-4D17-8DA7-6B09E0206C38 Q33771171-8C6D23C4-6670-4E44-89B5-DC3C098B421C Q33830137-BBE53B1F-EBB3-4755-BC1F-34B23EE3A2CE Q33866039-2A173531-D5F2-4234-A9BE-885D96CC3E67 Q33945108-DE9B2F0A-4F08-420D-9269-56707F7B679C Q33995580-AAFEE894-80AA-48C0-BB9E-75BC1D5F02AE Q34273807-4866692A-1EFA-4959-9E0A-0A59AB66A21A Q34348323-26221AA4-6560-4D41-80D6-FA78F2EBD448 Q34431008-346B2F09-50A4-4B39-8CA5-42232AF64CC7 Q34603092-70D32177-53DB-4FA0-A3ED-C32A3A72D6AF Q34651878-B8FF04DA-B7A4-4AE0-833F-9577833917BC Q34760604-CBD1126D-7EDD-4304-BC3E-E6A0939D8D10 Q34761039-ECCF160C-CD30-44BE-9010-7C85BCD110B2 Q34808510-CDF33188-D8BD-488A-81C8-78CDCE975602 Q34890228-CFC78240-97D1-464E-A210-AEE0323EC544 Q34951817-29B0E09B-D86A-467E-A7A6-CE696D813A65 Q34978900-04805732-70DC-46A6-9F40-BE84547D107D Q35166985-A8BFB520-1D6F-4691-B025-30AD94951033 Q35334161-5F177DED-2460-46FE-B98E-7162B406D439 Q35418351-3B99264C-2EF5-45A6-BD7B-7EE9DD813CA5 Q35662397-9363CC60-AAFB-4ABF-80FB-F3124DC158CE Q35694025-E4063B3B-6AD3-426C-B9D4-56B8E5806122 Q35995939-8A3879A1-3DF1-4B8E-A5E2-B3DB3D9F764E Q36034035-514D37FA-67AA-4DFF-A587-88ADCBF87689 Q36065117-677DB642-6698-4F56-9CD4-D75099A8F347

P2860

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

http://www.wikidata.org/entity/Q45993868

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@en

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@nl

type

label

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@en

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@nl

prefLabel

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@en

Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.

@nl

P1433

Q45993868-17691F9D-93C6-4573-B348-9DACE14F5638

P1476

Q45993868-75A62514-C1B6-4DAC-9461-9F36A0C3F6A2

P2093

Q45993868-010612AC-BB7C-49EE-B71E-05DEE0465477

Q45993868-0376174B-F2B2-478C-816C-D4525E86B467

Q45993868-246D13AC-4919-410C-9C00-5FE0254CDACD

Q45993868-2FA43A25-1BDC-4588-B183-49F58ED2C617

Q45993868-5CA3E7BA-2AF1-4A2B-892C-E6A98E099A0A

Q45993868-6E58993A-5858-4AB8-A5AF-6B50AB790514

Q45993868-9CAE0B4D-DDF7-45AB-96F5-1CE71E2B3C18

Q45993868-C9CD7B11-9CD0-489C-8748-9F2C01657AAD

Q45993868-E2AEFCB7-6A70-40AF-89D3-AFB3A32EC87F

P304

Q45993868-901154F1-6957-4665-9329-FF1F93B4A97A

P31

Q45993868-BA9EC8B3-DAEF-4CA0-B001-D9B86F662AD4

P356

Q45993868-5273C329-F140-44D3-ACA8-04EC8F94B28B

P407

Q45993868-A45D1D5F-100E-4CB3-B3DB-69FB26BA6BC6

P433

Q45993868-03BD8A75-6025-4BFC-AA98-893160C3B44E

P478

Q45993868-532DEA00-C340-44C2-9952-3FD2CBD409E1

P577

Q45993868-F7DDEB41-D165-433C-9086-6985528A924B

P698

Q45993868-1E790F02-6123-4D2D-911F-43F319B1E178

P932

Q45993868-55CC9F7E-A76B-4759-AF90-9B599F350BFE

P356

JNEUROSCI.0887-09.2009

P1433

Journal of Neuroscience

P1476

Human APOE isoform-dependent e ...... evels in PDAPP transgenic mice

@en

P2093

Cynthia DeLong

http://www.w3.org/2001/XMLSchema#string

Deanna Koger

http://www.w3.org/2001/XMLSchema#string

Feng Liu

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Hansen

http://www.w3.org/2001/XMLSchema#string

Kelly R Bales

http://www.w3.org/2001/XMLSchema#string

Patrick M Sullivan

http://www.w3.org/2001/XMLSchema#string

Steven M Paul

http://www.w3.org/2001/XMLSchema#string

Su Wu

http://www.w3.org/2001/XMLSchema#string

Suizhen Lin

http://www.w3.org/2001/XMLSchema#string

P304

6771-6779

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1523/JNEUROSCI.0887-09.2009

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P577

2009-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19474305

http://www.w3.org/2001/XMLSchema#string

P932

6665579

http://www.w3.org/2001/XMLSchema#string