Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
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Alzheimer mechanisms and therapeutic strategiesHuman APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer modelImpact of apolipoprotein E on Alzheimer's diseaseGenes associated with Alzheimer's disease: an overview and current statusApolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's diseaseInsulin: an emerging treatment for Alzheimer's disease dementia?Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseasesGenetic variants associated with neurodegenerative Alzheimer disease in natural modelsACAT1/SOAT1 as a therapeutic target for Alzheimer's diseaseApolipoprotein E and Alzheimer disease: risk, mechanisms and therapyIdentification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in AstrocytesIn vivo human apolipoprotein E isoform fractional turnover rates in the CNSThe ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated miceStem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death.Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Accumulation of intraneuronal Abeta correlates with ApoE4 genotypeHuman APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African AmericansLCAT deficiency does not impair amyloid metabolism in APP/PS1 miceIn vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathologyA multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier.Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.The role of apolipoprotein E in Alzheimer's disease.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse modelApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 miceApolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interactionTransgenic animal models of neurodegeneration based on human genetic studies.Function and comorbidities of apolipoprotein e in Alzheimer's disease.Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement miceHuman apoE isoforms differentially regulate brain amyloid-β peptide clearanceIntroducing Human APOE into Aβ Transgenic Mouse Models.Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic miceCombined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice
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P2860
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@en
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@nl
type
label
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@en
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@nl
prefLabel
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@en
Human APOE isoform-dependent e ...... vels in PDAPP transgenic mice.
@nl
P2093
P1476
Human APOE isoform-dependent e ...... evels in PDAPP transgenic mice
@en
P2093
Cynthia DeLong
Deanna Koger
Jeffrey C Hansen
Kelly R Bales
Patrick M Sullivan
Steven M Paul
Suizhen Lin
P304
P356
10.1523/JNEUROSCI.0887-09.2009
P407
P577
2009-05-01T00:00:00Z