Cooperation between constitutively activated c-Kit signaling and leukemogenic transcription factors in the determination of the leukemic phenotype in murine hematopoietic stem cells.
about
The origin and evolution of mutations in acute myeloid leukemiaC-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in miceSTAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AMLMutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activityBortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.
P2860
Cooperation between constitutively activated c-Kit signaling and leukemogenic transcription factors in the determination of the leukemic phenotype in murine hematopoietic stem cells.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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name
Cooperation between constituti ...... rine hematopoietic stem cells.
@en
Cooperation between constituti ...... rine hematopoietic stem cells.
@nl
type
label
Cooperation between constituti ...... rine hematopoietic stem cells.
@en
Cooperation between constituti ...... rine hematopoietic stem cells.
@nl
prefLabel
Cooperation between constituti ...... rine hematopoietic stem cells.
@en
Cooperation between constituti ...... rine hematopoietic stem cells.
@nl
P2093
P1476
Cooperation between constituti ...... rine hematopoietic stem cells.
@en
P2093
Claudia Oancea
Martin Ruthardt
Reinhard Henschler
Xiaomin Zheng
P304
P577
2009-06-01T00:00:00Z