p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.
about
Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer TherapyTumor suppressor p53 and its mutants in cancer metabolismP53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapyThe p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humansMisfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Cancer: A piece of the p53 puzzle.Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.Mutant TP53 posttranslational modifications: challenges and opportunities.Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis.Ferroptosis as a p53-mediated activity during tumour suppressionWild type p53 reactivation: from lab bench to clinic.Development of cancer-initiating cells and immortalized cells with genomic instability.Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer DevelopmentProgrammed cell death in aging.Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKTMieap suppresses murine intestinal tumor via its mitochondrial quality control.The BCL-2 protein family, BH3-mimetics and cancer therapy.Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.p53 genes function to restrain mobile elementsTransglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.FoxO3 suppresses Myc-driven lymphomagenesis.Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature agingp19(Arf) is required for the cellular response to chronic DNA damageHuman pregnane X receptor compromises the function of p53 and promotes malignant transformationPUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.Identification of cellular senescence-specific genes by comparative transcriptomics.RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.A platform for interrogating cancer-associated p53 alleles.A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responsesp53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.A mechanism for 1,4-Benzoquinone-induced genotoxicity.Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression.Tumor suppression by p53 involves inhibiting an enabler, FGF13.p53 activity is selectively licensed in the Drosophila stem cell compartment.To be, or not to be: functional dilemma of p53 metabolic regulation.
P2860
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P2860
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@en
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@nl
type
label
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@en
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@nl
prefLabel
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@en
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa.
@nl
P50
P1433
P1476
p53 efficiently suppresses tum ...... effectors p21, Puma, and Noxa
@en
P2093
Clare L Scott
P304
P356
10.1016/J.CELREP.2013.04.012
P50
P577
2013-05-09T00:00:00Z