about
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenitePuma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationER stress triggers apoptosis by activating BH3-only protein BimInterleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice.p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.Using the GEMM-ESC strategy to study gene function in mouse models.Subversion of the Bcl-2 life/death switch in cancer development and therapy.Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoidsThe roles of DNA, RNA and histone methylation in ageing and cancer
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Ewa Michalak
@en
Ewa Michalak
@nl
type
label
Ewa Michalak
@en
Ewa Michalak
@nl
prefLabel
Ewa Michalak
@en
Ewa Michalak
@nl
P31
P496
0000-0002-5772-2122