Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
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Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesisGlypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cellsQSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signalingDeterminants of Glycosaminoglycan (GAG) StructureCan we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.Crystal Structure of N -Glycosylated Human Glypican-1 Core ProteinAgrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clustersOn the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesisModulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis. Mapping of spermine-binding sites and heparanase, heparin lyase, and nitric oxide/nitrite cleavage sites.Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes.Cell surface heparan sulfate and its roles in assisting viral infections.Mammalian heparanase: what is the message?A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesisGlycans as receptors for influenza pathogenesisGlypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells.Glypican-1 as a Biomarker for Prostate Cancer: Isolation and CharacterizationInvestigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation.Shaping morphogen gradients by proteoglycansThe tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions.A spoonful of sugar makes the melanoma go: the role of heparan sulfate proteoglycans in melanoma metastasis.Heparan sulfate biosynthesis: regulation and variability.Recombinant production of proteoglycans and their bioactive domains.Expression of collagen XVIII and localization of its glycosaminoglycan attachment sites.Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells. Common phosphorylation of xylose and differential sulfation of galactose in the protein linkage region tProcessing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.Sugar tags and tumorigenesis.Analyzing the role of heparan sulfate proteoglycans in axon guidance in vivo in zebrafish.In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction.Two functional domains in C. elegans glypican LON-2 can independently inhibit BMP-like signaling.
P2860
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P2860
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@en
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@nl
type
label
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@en
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@nl
prefLabel
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@en
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@nl
P2860
P356
P1476
Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.
@en
P2093
P2860
P304
P356
10.1074/JBC.M008283200
P407
P577
2000-12-05T00:00:00Z