PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. - Wikidata - awgldk - TriplyDB

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis.

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis.

http://www.wikidata.org/entity/Q46129869

about

SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma.Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer.Regulation of the pentose phosphate pathway in cancer microRNA-141 inhibits cell proliferation and invasion and promotes apoptosis by targeting hepatocyte nuclear factor-3β in hepatocellular carcinoma cells.Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden.HnRNPK/miR-223/FBXW7 feedback cascade promotes pancreatic cancer cell growth and invasion.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.G6PD downregulation triggered growth inhibition and induced apoptosis by regulating STAT3 signaling pathway in esophageal squamous cell carcinoma.Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers.Down-regulation of DAB2IP promotes colorectal cancer invasion and metastasis by translocating hnRNPK into nucleus to enhance the transcription of MMP2.High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells.ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer.Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53 Evaluation and prediction of hepatocellular carcinoma prognosis based on molecular classification

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P2860

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis.

http://www.wikidata.org/entity/Q46129869

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-my

2013年学术文章

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2013年學術文章

@yue

2013年學術文章

@zh-hant

name

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

@en

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

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type

label

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

@en

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

@nl

prefLabel

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

@en

PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

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PTEN antagonises Tcl1/hnRNPK-m ...... butes to hepatocarcinogenesis.

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Huiwen Song

http://www.w3.org/2001/XMLSchema#string

Jiabei Wang

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Lianxin Liu

http://www.w3.org/2001/XMLSchema#string

Ruipeng Song

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Shuyi Qi

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Tongsen Zheng

http://www.w3.org/2001/XMLSchema#string

Xuan Song

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Yingjian Liang

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Zhaoyang Lu

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P2860

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

The protooncogene TCL1 is an Akt kinase coactivator

hnRNP K: one protein multiple processes

Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells

An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA

Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies.

Regulation of the processing of glucose-6-phosphate dehydrogenase mRNA by nutritional status.

Identification of hnRNPs K, L and A2/B1 as candidate proteins involved in the nutritional regulation of mRNA splicing

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a tissue biomarker for detection of early hepatocellular carcinoma in patients with cirrhosis.

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1635-1647

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