Formation of a highly peptide-receptive state of class II MHC.
about
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsSurface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivityExploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IIAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionEnhancement of tumour-specific immune responses in vivo by 'MHC loading-enhancer' (MLE)Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideAnchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesModel for the peptide-free conformation of class II MHC proteins.Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange.Characterization of structural features controlling the receptiveness of empty class II MHC molecules.The kinetic basis of peptide exchange catalysis by HLA-DMInterpretation of biphasic dissociation kinetics for isomeric class II major histocompatibility complex-peptide complexes.Function-related regulation of the stability of MHC proteins.Translational diffusion of individual class II MHC membrane proteins in cellsCholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membrane.For many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selectionConformational-relaxation models of single-enzyme kinetics.Boosting immune response with the invariant chain segments via association with non-peptide binding region of major histocompatibility complex class II molecules.HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.Binding interactions between peptides and proteins of the class II major histocompatibility complex.The melting pot of the MHC II peptidomeThe convergent roles of tapasin and HLA-DM in antigen presentation.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathwayEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.Catalysis of peptide dissociation from class II MHC-peptide complexes.Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.Abundant empty class II MHC molecules on the surface of immature dendritic cells.Memory landscapes of single-enzyme molecules.In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Enhancing tumor vaccines: catalyzing MHC class II peptide exchange.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.HLA-DM: arbiter conformationis.
P2860
Q26747063-BF443D52-0B87-46DF-A126-53F922B984F7Q27333772-0AD0E264-5D6E-459A-8F15-138BAD7AEA22Q27641946-A32B0707-DE61-469A-B8EF-1583C5FF6148Q27675568-89B32B0E-DE29-4655-A78E-A3ED7C15267FQ27679799-0E7E62C8-CE79-4BFC-A17E-E603930C98E9Q28273723-B66F7BA0-72F7-476A-ACE1-E9CA7EA8C8F2Q28476101-F16D6BED-C39B-42C1-B7BE-887B8FBF7506Q33258637-10D14089-76C3-4758-9509-9FBFB6331A11Q33292091-6DA774E2-5B00-494F-AD7E-6DD411B8FC2DQ33324394-BDC8027F-0676-4653-9DDA-7572A4700666Q33342783-933E47F6-99A8-4DEB-9163-7F8D8E498A3EQ33815440-57F42D45-3AA4-4687-A605-F5CB221DD251Q33886577-09997941-340E-44A5-BAF5-8AD7F7A183C4Q33947777-B36114FF-2D26-4CB6-BCBD-1886D7E77C7DQ34171654-40EF26B4-9421-4903-8307-468637E0DA03Q34174199-F5BA5744-7FD8-46C1-940D-4845D0F824F7Q34179163-DE08872F-809D-4E2B-88EC-8984D220B2D1Q34188496-3F04DC21-D405-40B5-A69B-5DFB9B49AADCQ34338884-26AF7FCE-5C51-47D7-BD5C-19236593DEE0Q34386513-8CB80BBD-6B38-4F13-9606-16B427D13AFBQ34422852-1DB4ED94-D10B-43E0-A78E-83E6300E84F8Q34483195-0C0294C7-1BB9-4194-9ACB-364A47597E74Q34540061-EAE24A48-DCC5-45F8-997E-7D817FF2CFD4Q34676583-C316C00E-3876-45B8-B469-6F72F299CB78Q34784992-621815A4-FF87-4246-82B8-38B39FBD57CFQ34948997-73D3AB63-D980-40FB-B869-6C78B64F79B4Q35785432-ECD82C95-8F9C-4F9D-BB86-BDCFB4D7307DQ35815584-121A061C-5730-4D0C-B233-3F98BC4852B2Q36189571-D970EF80-9123-44C2-9F37-9A8A5BB9E5FBQ36375555-D1EC33AD-C9E7-4C73-8F9E-30C39A13338FQ36396787-8CFDA5A8-0BED-4657-8A1C-4424F962227DQ36404572-FA89ABAE-BAAB-4180-95EA-B19B116FC738Q36780413-C2EFC635-EF0C-4BDE-BF14-3563E0B9882AQ37220377-39BF3DAD-CBDD-4187-B2C9-F9D406A97B0BQ37224874-42592766-6C67-4213-8711-7DBB82023473Q37345643-475C9EFA-011E-4CAA-BA7F-BC77F5BFCFE4Q37672424-691C2B16-556C-4A19-8959-33293B89FDD1Q37682892-229B16F2-8F74-4628-8FE7-E8271271A930Q38050482-7D5FE813-45CA-410B-8C3D-8327EC597C8CQ38056763-477E70EF-C9ED-4889-895D-CECB801FF005
P2860
Formation of a highly peptide-receptive state of class II MHC.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Formation of a highly peptide-receptive state of class II MHC.
@en
Formation of a highly peptide-receptive state of class II MHC.
@nl
type
label
Formation of a highly peptide-receptive state of class II MHC.
@en
Formation of a highly peptide-receptive state of class II MHC.
@nl
prefLabel
Formation of a highly peptide-receptive state of class II MHC.
@en
Formation of a highly peptide-receptive state of class II MHC.
@nl
P2093
P1433
P1476
Formation of a highly peptide-receptive state of class II MHC
@en
P2093
H M McConnell
J D Rabinowitz
J J Boniface
P304
P356
10.1016/S1074-7613(00)80667-6
P407
P577
1998-11-01T00:00:00Z