HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
about
Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitorSmall molecules that enhance the catalytic efficiency of HLA-DMHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsStructure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetesThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideExogenous antigens bind MHC class II first, and are processed by cathepsins laterAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionSmall organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideAnchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesModel for the peptide-free conformation of class II MHC proteins.HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.The kinetic basis of peptide exchange catalysis by HLA-DMCutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMSurvey of the year 2000 commercial optical biosensor literature.HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.Binding interactions between peptides and proteins of the class II major histocompatibility complex.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.The convergent roles of tapasin and HLA-DM in antigen presentation.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Inhalational anesthetics disrupt postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1 domain protein interactions critical to action of several excitatory receptor channels related to anesthesia.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityThe optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.Right place, right time, right peptide: DO keeps DM focused.Conformational isomers of a peptide-class II major histocompatibility complex.Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor.Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design.Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.
P2860
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P2860
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@ast
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@en
type
label
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@ast
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@en
prefLabel
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@ast
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@en
P2860
P356
P1476
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
@en
P2093
S Sadegh-Nasseri
P2860
P304
P356
10.1084/JEM.192.12.1697
P407
P577
2000-12-01T00:00:00Z