Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
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A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityAmyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differencesPutative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's DiseaseUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesMolecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes MellitusRedox control of protein degradationTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseMisfolding and amyloid aggregation of apomyoglobinDye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assemblyTowards a Pharmacophore for AmyloidMolecular basis for amyloid- polymorphismMeasurement of amyloid formation by turbidity assay-seeing through the cloudModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusSystematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's diseaseSequestration of the Abeta peptide prevents toxicity and promotes degradation in vivoComplete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitorInhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesCurcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic DrosophilaHalogenation generates effective modulators of amyloid-Beta aggregation and neurotoxicity.Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid ProteinsOral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.Nucleus factory on cavitation bubble for amyloid β fibril.Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living CellsA safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregatesSimultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesisC-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.Structural classification of toxic amyloid oligomersAlpha-helix targeting reduces amyloid-beta peptide toxicity.Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.Potency of a tau fibrillization inhibitor is influenced by its aggregation stateClioquinol and other hydroxyquinoline derivatives inhibit Abeta(1-42) oligomer assembly.Effect of metals on kinetic pathways of amyloid-β aggregationAmyloid structure and assembly: insights from scanning transmission electron microscopy.Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's diseaseLinking amyloid protein aggregation and yeast survival.Tissue transglutaminase-mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregationIn silico theoretical molecular modeling for Alzheimer's disease: the nicotine-curcumin paradigm in neuroprotection and neurotherapy.
P2860
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P2860
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Small molecule inhibitors of a ...... are independent and distinct.
@en
Small molecule inhibitors of a ...... are independent and distinct.
@nl
type
label
Small molecule inhibitors of a ...... are independent and distinct.
@en
Small molecule inhibitors of a ...... are independent and distinct.
@nl
prefLabel
Small molecule inhibitors of a ...... are independent and distinct.
@en
Small molecule inhibitors of a ...... are independent and distinct.
@nl
P2093
P356
P1476
Small molecule inhibitors of a ...... are independent and distinct.
@en
P2093
Charles G Glabe
Mihaela Necula
Rakez Kayed
Saskia Milton
P304
10311-10324
P356
10.1074/JBC.M608207200
P407
P577
2007-02-06T00:00:00Z