Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
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Molecular mechanisms of antiseizure drug activity at GABAA receptorsAcetazolamide and midazolam act synergistically to inhibit neuropathic pain.α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders.The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain.Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.Reduced GABA(A) receptor α6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivityModulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomesHZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic painSingle dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability.Fast synaptic inhibition in spinal sensory processing and pain control.Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.The α5 subunit containing GABAA receptors contribute to chronic pain.Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sitesInhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.GABA and central neuropathic pain following spinal cord injuryUse of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.Benzodiazepine receptor ligands: a patent review (2006-2012).Analgesic effect of clobazam in chronic low-back pain but not in experimentally induced pain.Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024.α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia.An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists.Comparative evaluation of effect of preoperative alprazolam and diclofenac potassium on the success of inferior alveolar, Vazirani-Akinosi, and Gow-Gates techniques for teeth with irreversible pulpitis: Randomized controlled trial.Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.Pain free and awake to enjoy it!sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study.Long-term actions of BDNF on inhibitory synaptic transmission in identified neurons of the rat substantia gelatinosa.Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect
P2860
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P2860
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@en
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@nl
type
label
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@en
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@nl
prefLabel
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@en
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@nl
P2093
P1433
P1476
Genuine antihyperalgesia by sy ...... A receptor point-mutated mice.
@en
P2093
Florence Crestani
Hanns Ulrich Zeilhofer
Julia Knabl
Ulrike B Zeilhofer
Uwe Rudolph
P304
P356
10.1016/J.PAIN.2008.10.015
P407
P577
2008-12-16T00:00:00Z