Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
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HIV-1 integrase crosslinked oligomers are active in vitroPre-organized structure of viral DNA at the binding-processing site of HIV-1 integraseStructural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase.Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingRevealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteinsAn unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA bindingGenetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Division of labor within human immunodeficiency virus integrase complexes: determinants of catalysis and target DNA captureMetal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitroRelationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity.Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.Computer tools in the discovery of HIV-1 integrase inhibitorsThe role of lysine 186 in HIV-1 integrase multimerizationC-Terminal Domain of Integrase Binds between the Two Active SitesNovel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of actionIdentifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase.Integrase and integration: biochemical activities of HIV-1 integrase.Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration.HIV-1 Integrase-DNA Recognition Mechanisms.Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.The conformational feasibility for the formation of reaching dimer in ASV and HIV integrase: a molecular dynamics study.Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solutionThe dynamics of interconverting D- and E-forms of the HIV-1 integrase N-terminal domain.Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat Ends.Structural dynamics of full-length retroviral integrase: a molecular dynamics analysis.HIV-1 IN alternative molecular recognition of DNA induced by raltegravir resistance mutations.
P2860
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P2860
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@en
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@nl
type
label
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@en
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@nl
prefLabel
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@en
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@nl
P2093
P356
P1433
P1476
Modeling HIV-1 integrase complexes based on their hydrodynamic properties.
@en
P2093
Alexei A Podtelezhnikov
Frederic D Bushman
P304
P356
10.1002/BIP.10217
P577
2003-01-01T00:00:00Z