Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. - Wikidata - awgldk - TriplyDB

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

http://www.wikidata.org/entity/Q46347859

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How bacteria control the CRISPR-Cas arsenal.Gene Editing in Human Lymphoid Cells: Role for Donor DNA, Type of Genomic Nuclease and Cell Selection Method.Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains.Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.Applications of Alternative Nucleases in the Age of CRISPR/Cas9.In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease.High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing.The Council of Europe should not reaffirm the ban on germline genome editing in humans.Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection.Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs.A highly specific SpCas9 variant is identified by in vivo screening in yeast.Precise Cas9 targeting enables genomic mutation prevention.Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention.Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.Microhomology-assisted scarless genome editing in human iPSCs.Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.Insights into maize genome editing via CRISPR/Cas9.CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection.CRISPR/Cas9 and Genome Editing for Viral Disease-Is Resistance Futile?Feasibility of a Conditional Knockout System for Chlamydia Based on CRISPR Interference.Real-time observation of flexible domain movements in CRISPR-Cas9.Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action.Naxos disease: from the origin to today.Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair.A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice.Directed evolution of CRISPR-Cas9 to increase its specificity Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair Gene editing in the context of an increasingly complex genome High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells CRISPR/Cas9 System: A Bacterial Tailor for Genomic Engineering Blossom of CRISPR technologies and applications in disease treatment Diverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attB Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

http://www.wikidata.org/entity/Q46347859

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

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Alexander A Sousa

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J Keith Joung

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Janice S Chen

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Jennifer A Doudna

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Lucas B Harrington

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Moira M Welch

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Samuel H Sternberg

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Yavuz S Dagdas

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Cas9 as a versatile tool for engineering biology

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

Development and applications of CRISPR-Cas9 for genome engineering.

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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407-410

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10.1038/NATURE24268

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7676

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550

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Benjamin P Kleinstiver

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2017-09-20T00:00:00Z

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1091860712

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