Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
about
Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function.Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer's disease model.A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets.Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes
P2860
Q38907710-04BF1180-2C9C-416E-9164-42A4E476B877Q42375968-7E1A067B-22F7-4C3A-99E8-9DEDFA3D2744Q47233632-F9BD733B-A915-4DAB-9C88-FFA13E14BF62Q48724578-1CD80067-60C3-499B-BDE5-AF6EF9B1AB9FQ49367941-4C880F85-F0B6-4E7D-BD2F-2E94574C1790Q50058144-97C2A6C3-366E-481C-9A52-DE4BD7E6E3C1Q52659229-2B50406E-8ED7-40A6-843E-BC31BD12875CQ58554232-ADB5E135-020B-4F96-BEC7-3212082CF205
P2860
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@en
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@nl
type
label
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@en
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@nl
prefLabel
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@en
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.
@nl
P2093
P2860
P356
P1476
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway
@en
P2093
Daniel A Cunha
Décio L Eizirik
Jean-Marie Vanderwinden
Miriam Cnop
Monia Cito
Per-Ola Carlsson
Piero Marchetti
P2860
P2888
P304
P356
10.1038/CDD.2016.89
P577
2016-09-02T00:00:00Z