PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism.
about
E-type prostanoid receptor 4 (EP4) in disease and therapyCyclooxygenase-1 as the main source of proinflammatory factors after sodium orthovanadate treatmentEP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease.Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activationEvidence for a spatial and temporal regulation of prostaglandin-endoperoxide synthase 2 expression in human amnion in term and preterm parturitionA maladaptive role for EP4 receptors in podocytesUnderstanding the role of prostaglandin E2 in regulating human platelet activity in health and diseaseAlbumin-induced podocyte injury and protection are associated with regulation of COX-2.cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion.Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injuryFeedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo.Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease.Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells.Distinct roles for basal and induced COX-2 in podocyte injuryFluid flow shear stress over podocytes is increased in the solitary kidney.Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction.Cyclooxygenase metabolites in the kidney.Chronic kidney disease: targeting prostaglandin E2 receptors.Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2.Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney.CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation.Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats.Transforming growth factor-β1 and phosphatases modulate COX-2 protein expression and TAU phosphorylation in cultured immortalized podocytes.Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF).The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway.Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema.
P2860
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P2860
PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
PGE(2) induces COX-2 expressio ...... h a PKA-independent mechanism.
@en
type
label
PGE(2) induces COX-2 expressio ...... h a PKA-independent mechanism.
@en
prefLabel
PGE(2) induces COX-2 expressio ...... h a PKA-independent mechanism.
@en
P1433
P1476
PGE(2) induces COX-2 expressio ...... h a PKA-independent mechanism.
@en
P2093
Christopher R J Kennedy
Kaede Gomi
P304
P356
10.1016/J.CELLSIG.2008.08.007
P577
2008-08-15T00:00:00Z