Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
about
Structure-guided design of selective Epac1 and Epac2 agonistsGLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependenceCyclic AMP dynamics in the pancreatic β-cellA fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonistscAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasionIsoform-specific antagonists of exchange proteins directly activated by cAMPCyclic AMP sensor EPAC proteins and energy homeostasis.Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.EP2 receptor signaling pathways regulate classical activation of microglia.Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.Epac proteins: specific ligands and role in cardiac remodelling.Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP.Effects of sodium ions on rat thyrocyte (FRTL-5 cells) swelling- and thyrotropin-activated taurine efflux dependent on cAMP and Epac.Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue.The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
P2860
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P2860
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@en
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@nl
type
label
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@en
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@nl
prefLabel
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@en
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@nl
P2093
P2860
P356
P1476
Enhanced Rap1 activation and i ...... s with 8-pCPT-2'-O-Me-cAMP-AM.
@en
P2093
Colin A Leech
Elvira Dzhura
Frank Schwede
George G Holz
Grant G Kelley
Hans G Genieser
Igor Dzhura
Michael J Rindler
Oleg G Chepurny
Xiangquan Li
P2860
P304
10728-10736
P356
10.1074/JBC.M900166200
P407
P577
2009-02-25T00:00:00Z