Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells.
about
GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseIntrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury.Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype.Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase GSildenafil suppresses the proliferation and enhances the apoptosis of hemangioma endothelial cells.cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanismcGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages.Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activityThe cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects.Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: opportunities and obstacles for survival signaling.OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer TherapiesNexavar/Stivarga and viagra interact to kill tumor cells.GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Safety of sildenafil in the treatment of erectile dysfunction in patients with obstructive sleep apnoea.Soluble guanylyl cyclase contributes to ventilator-induced lung injury in miceDevelopmental toxicity of orally administered sildenafil citrate (Viagra) in SWR/J mice.Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentAnti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.Why vessels do matter in pulmonary disease.Development of a new method for the isolation and culture of pulmonary arterial endothelial cells from rat pulmonary arteries.
P2860
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P2860
Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@en
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@nl
type
label
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@en
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@nl
prefLabel
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@en
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@nl
P2093
P2860
P1476
Cyclic GMP-specific phosphodie ...... n pulmonary endothelial cells.
@en
P2093
Samuel Strada
Troy Stevens
P2860
P304
P356
10.1152/AJPLUNG.00433.2004
P577
2005-03-25T00:00:00Z