about
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsRapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activationTranscriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient miceThe many functions of APE1/Ref-1: not only a DNA repair enzymeA DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsNew evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions.DNA repair deficiency in neurodegeneration.Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar DepressionGenome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.DNA damage responses in neural cells: Focus on the telomereCommentary: DNA base excision repair defects in human pathologies.Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairmentDefective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.Base excision repair in physiology and pathology of the central nervous systemBase excision repair, aging and health span.Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's diseaseDNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.Brain capacity for repair of oxidatively damaged DNA and preservation of neuronal function.Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitroMitochondrial DNA repair in aging and diseaseDNA base excision repair activities in mouse models of Alzheimer's disease.Human apurinic/apyrimidinic endonuclease 1.DNA Repair Defects and DNA-PK in Neurodegeneration.Base excision repair of oxidative DNA damage: from mechanism to disease.The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Is DNA repair compromised in Alzheimer's disease?
@en
Is DNA repair compromised in Alzheimer's disease?
@nl
type
label
Is DNA repair compromised in Alzheimer's disease?
@en
Is DNA repair compromised in Alzheimer's disease?
@nl
prefLabel
Is DNA repair compromised in Alzheimer's disease?
@en
Is DNA repair compromised in Alzheimer's disease?
@nl
P2093
P1476
Is DNA repair compromised in Alzheimer's disease?
@en
P2093
Deborah A Shackelford
Lawrence A Hansen
Vladislav Davydov
P304
P356
10.1016/S0197-4580(02)00229-4
P577
2003-11-01T00:00:00Z