Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion.
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Systems Biology Approaches to Understand Natural Products Biosynthesis¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixationSynthetic promoter library for modulation of actinorhodin production in Streptomyces coelicolor A3(2).Robust, small-scale cultivation platform for Streptomyces coelicolorMetabolic modeling and analysis of the metabolic switch in Streptomyces coelicolorThe CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitroThe construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters.Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa.Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.Semi-automated curation of metabolic models via flux balance analysis: a case study with Mycoplasma gallisepticumCarbon-flux distribution within Streptomyces coelicolor metabolism: a comparison between the actinorhodin-producing strain M145 and its non-producing derivative M1146.Comparative Proteomic Analysis of saccharopolyspora spinosa SP06081 and PR2 strains reveals the differentially expressed proteins correlated with the increase of spinosad yield.Accomplishments in genome-scale in silico modeling for industrial and medical biotechnologyGamma-butyrolactone regulatory system of Streptomyces chattanoogensis links nutrient utilization, metabolism, and development.The return of metabolism: biochemistry and physiology of the pentose phosphate pathwayIdentification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy.Identification of a cyclosporine-specific P450 hydroxylase gene through targeted cytochrome P450 complement (CYPome) disruption in Sebekia benihana.Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvementProduction of microbial secondary metabolites: regulation by the carbon source.Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103.Carbon source regulation of antibiotic production.Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in StreptomycesThe regulation of the secondary metabolism of Streptomyces: new links and experimental advances.Genome-scale metabolic model in guiding metabolic engineering of microbial improvement.Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439.Engineering microbial hosts for production of bacterial natural productsMetabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites.Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces.Characterization of recombinant UDP- and ADP-glucose pyrophosphorylases and glycogen synthase to elucidate glucose-1-phosphate partitioning into oligo- and polysaccharides in Streptomyces coelicolor.Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor.Genome-based studies of marine microorganisms to maximize the diversity of natural products discovery for medical treatmentsAn insight into the "-omics" based engineering of streptomycetes for secondary metabolite overproduction.Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2).Carbon catabolite regulation in Streptomyces: new insights and lessons learned.Characterization of the chromosomal integration of Saccharopolyspora plasmid pCM32 and its application to improve production of spinosyn in Saccharopolyspora spinosa.Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production.Iterative marker excision system.Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters.Expanding Primary Metabolism Helps Generate the Metabolic Robustness To Facilitate Antibiotic Biosynthesis in Streptomyces.
P2860
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P2860
Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@en
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@nl
type
label
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@en
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@nl
prefLabel
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@en
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@nl
P2093
P2860
P50
P356
P1476
Antibiotic overproduction in S ...... phosphofructokinase deletion.
@en
P2093
Colin P Smith
Geertje van Keulen
Jeroen Siebring
P2860
P304
25186-25199
P356
10.1074/JBC.M803105200
P407
P577
2008-07-07T00:00:00Z