In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models.
about
Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel OpenerNeural KCNQ (Kv7) channelsIon channels as drug targets in central nervous system disordersThe riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potentialN-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of EpilepsyIsoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactionsVoltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and ContractilityOne man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.Kv7 potassium channel activation with ICA-105665 reduces photoparoxysmal EEG responses in patients with epilepsy.Voltage-gated potassium channels as therapeutic targets.Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.HCN and KV7 (M-) channels as targets for epilepsy treatment.Pharmacological considerations in the use of stiripentol for the treatment of epilepsy.Potassium Channels in Epilepsy.Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants.Activation of peripheral KCNQ channels attenuates inflammatory pain.[EXPRESS] RNA interference-based functional knockdown of the voltage gated potassium channel Kv7.2 in dorsal root ganglion neurons after in vitro and in vivo gene transfer by adeno-associated virus (AAV) vectors.A resurging boom in new drugs for epilepsy and brain disorders.Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.
P2860
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P2860
In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
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2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@en
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@nl
type
label
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@en
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@nl
prefLabel
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@en
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@nl
P2093
P356
P1476
In vivo profile of ICA-27243 [ ...... rodent anticonvulsant models.
@en
P2093
Alan D Wickenden
Christopher Crean
Grant McNaughton-Smith
Greg C Rigdon
James O McNamara
James Stables
Neil Ghodadra
Rosemarie Roeloffs
Stephen Werness
P304
P356
10.1124/JPET.108.137794
P407
P577
2008-06-24T00:00:00Z