Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node.
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The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeatThree-dimensional distribution of ryanodine receptor clusters in cardiac myocytesHierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells.RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivationSynchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cellsCalcium and arrhythmogenesis.Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells.The mitochondrial uniporter controls fight or flight heart rate increases.Modern perspectives on numerical modeling of cardiac pacemaker cellWhat keeps us ticking: a funny current, a calcium clock, or both?STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors.The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.Calmodulin kinase II is required for fight or flight sinoatrial node physiologyGenesis and regulation of the heart automaticity.Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsRegulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design.Beta-adrenergic receptor signaling in the heart: role of CaMKII.Contributions of cardiac "funny" (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial nodeFundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.Mechanism of pacemaking in I(K1)-downregulated myocytes.CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases.Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.Editorial: Ca(2+) Signaling and Heart Rhythm.Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cellsCa2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current.Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node.Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node.Ca(2+)-activated Cl(-) current in rabbit sinoatrial node cells.Sympathetic control of heart rate in nNOS knockout mice.Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.
P2860
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P2860
Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Localisation and functional si ...... e guinea-pig sino-atrial node.
@en
Localisation and functional si ...... e guinea-pig sino-atrial node.
@nl
type
label
Localisation and functional si ...... e guinea-pig sino-atrial node.
@en
Localisation and functional si ...... e guinea-pig sino-atrial node.
@nl
prefLabel
Localisation and functional si ...... e guinea-pig sino-atrial node.
@en
Localisation and functional si ...... e guinea-pig sino-atrial node.
@nl
P2093
P1476
Localisation and functional si ...... e guinea-pig sino-atrial node.
@en
P2093
P304
P356
10.1016/S0008-6363(00)00153-X
P577
2000-11-01T00:00:00Z