Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates.
about
Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and softwareAnalysis of publically available skin sensitization data from REACH registrations 2008-2014Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing.Assessing toxicological data quality: basic principles, existing schemes and current limitations.Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships.A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity.Non-animal test methods for predicting skin sensitization potentials.Photoprotection in changing times - UV filter efficacy and safety, sensitization processes and regulatory aspects.State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis.Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy.An in vitro human skin test for assessing sensitization potential.Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?Simulation of chemical metabolism for fate and hazard assessment. V. Mammalian hazard assessment.Development of an artificial neural network model for risk assessment of skin sensitization using human cell line activation test, direct peptide reactivity assay, KeratinoSens™ and in silico structure alert parameter.Application of IATA - A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization.TIMES-SS--recent refinements resulting from an industrial skin sensitisation consortium.Application of chemical reaction mechanistic domains to an ecotoxicity QSAR model, the KAshinhou Tool for Ecotoxicity (KATE).Reactivity of cosmetic UV filters towards skin proteins: model studies with Boc-lysine, Boc-Gly-Phe-Gly-Lys-OH, BSA and gelatin.How can structural similarity analysis help in category formation?§
P2860
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P2860
Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates.
description
2005 nî lūn-bûn
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2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Skin sensitization: modeling b ...... rmation of protein conjugates.
@en
Skin sensitization: modeling b ...... rmation of protein conjugates.
@nl
type
label
Skin sensitization: modeling b ...... rmation of protein conjugates.
@en
Skin sensitization: modeling b ...... rmation of protein conjugates.
@nl
prefLabel
Skin sensitization: modeling b ...... rmation of protein conjugates.
@en
Skin sensitization: modeling b ...... rmation of protein conjugates.
@nl
P2093
P2860
P1476
Skin sensitization: modeling b ...... rmation of protein conjugates.
@en
P2093
Gergana D Dimitrova
Jay Niemela
Lawrence K Low
Mike H I Comber
Ovanes G Mekenyan
Paul T Bailey
Petra S Kern
Richard D Phillips
Sabcho D Dimitrov
P2860
P304
P356
10.1080/10915810591000631
P577
2005-07-01T00:00:00Z