Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.
about
T cells and their eons-old obsession with MHCHigh frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnoverAutologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients.Escape from highly effective public CD8+ T-cell clonotypes by HIVHigh-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV controlClonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cells.A novel tuberculosis DNA vaccine in an HIV-1 p24 protein backbone confers protection against Mycobacterium tuberculosis and simultaneously elicits robust humoral and cellular responses to HIV-1Determinants of public T cell responses.Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoireTCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionInterrogating the relationship between naïve and immune antiviral T cell repertoiresBias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses.Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire.The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.Antiretroviral therapy reduces the magnitude and T cell receptor repertoire diversity of HIV-specific T cell responses without changing T cell clonotype dominance.Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease.Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
P2860
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P2860
Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Persistent survival of prevale ...... specific CD8+ T cell response.
@en
Persistent survival of prevale ...... specific CD8+ T cell response.
@nl
type
label
Persistent survival of prevale ...... specific CD8+ T cell response.
@en
Persistent survival of prevale ...... specific CD8+ T cell response.
@nl
prefLabel
Persistent survival of prevale ...... specific CD8+ T cell response.
@en
Persistent survival of prevale ...... specific CD8+ T cell response.
@nl
P2093
P50
P356
P1476
Persistent survival of prevale ...... -specific CD8+ T cell response
@en
P2093
Anthony D Kelleher
Daniel C Douek
David A Cooper
David J van Bockel
Hui Yee Greenaway
John Zaunders
Tedi E Asher
Vanessa Venturi
P304
P356
10.4049/JIMMUNOL.1001807
P407
P577
2010-12-06T00:00:00Z