An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.
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Na⁺ transport in the normal and failing heart - remember the balanceThe role of late I Na in development of cardiac arrhythmiasCaMKII-dependent regulation of cardiac Na(+) homeostasisMechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulenceNew treatment options for late Na current, arrhythmias, and diastolic dysfunctionPerspective: a dynamics-based classification of ventricular arrhythmiasA computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation.Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos?Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.Emerging clinical role of ranolazine in the management of angina.Ranolazine: a new approach to treating an old problem.Monogenic atrial fibrillation as pathophysiological paradigms.Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart modelElectrophysiologic basis for the antiarrhythmic actions of ranolazine.Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine.Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?Ranolazine versus amiodarone for prevention of postoperative atrial fibrillation.Role of late sodium channel current block in the management of atrial fibrillation.Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation.Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.The Effects of Ranolazine on Paroxysmal Atrial Fibrillation in Patients with Coronary Artery Disease: A Preliminary Observational Study.Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling.The QT interval and risk of incident atrial fibrillation.Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazineAntiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.Tolterodine reduces veratridine-augmented late INa, reverse-INCX and early afterdepolarizations in isolated rabbit ventricular myocytes.Heart failure modulates electropharmacological characteristics of sinoatrial nodes.Probucol prevents atrial ion channel remodeling in an alloxan-induced diabetes rabbit modelRanolazine: an antianginal drug with antiarrhythmic properties.Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias.The role of CaMKII in diabetic heart dysfunction.The late sodium current in heart failure: pathophysiology and clinical relevance.Ca²⁺-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2²⁺ affirming that increasing SERCA reduces aftercontractions.The association of QT interval components with atrial fibrillation.Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy.The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine.Frontal QRS-T Angle and the Risk of Atrial Fibrillation in the Elderly.Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.
P2860
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P2860
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
An increase of late sodium cur ...... d activity in atrial myocytes.
@en
An increase of late sodium cur ...... d activity in atrial myocytes.
@nl
type
label
An increase of late sodium cur ...... d activity in atrial myocytes.
@en
An increase of late sodium cur ...... d activity in atrial myocytes.
@nl
prefLabel
An increase of late sodium cur ...... d activity in atrial myocytes.
@en
An increase of late sodium cur ...... d activity in atrial myocytes.
@nl
P2093
P2860
P1476
An increase of late sodium cur ...... d activity in atrial myocytes.
@en
P2093
John C Shryock
Luiz Belardinelli
Yejia Song
P2860
P304
P356
10.1152/AJPHEART.01357.2007
P577
2008-02-29T00:00:00Z