Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. - Wikidata - awgldk - TriplyDB

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.

http://www.wikidata.org/entity/Q46769839

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Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.Elimination of self-reactive T cells in the thymus: a timeline for negative selection Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS)Long-term in vivo imaging of multiple organs at the single cell level T Cell Interstitial Migration: Motility Cues from the Inflamed Tissue for Micro- and Macro-Positioning Spatially resolved microfluidic stimulation of lymphoid tissue ex vivo.The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful.An extended vision for dynamic high-resolution intravital immune imaging.Hair loss and defective T- and B-cell function in mice lacking ORAI1 Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs The sense of place in the immune system.Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node.Opposing chemokine gradients control human thymocyte migration in situ Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Intravital two-photon microscopy: focus on speed and time resolved imaging modalities.Regulation of thymocyte positive selection and motility by GIT2.Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures Molecular basis of calcium signaling in lymphocytes: STIM and ORAI The immunological synapse: a dynamic platform for local signaling.T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo.Ex vivo imaging of T cells in murine lymph node slices with widefield and confocal microscopes.A requirement for sustained ERK signaling during thymocyte positive selection in vivo.Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.Tuning immune responses: diversity and adaptation of the immunological synapse.Calcium signaling in lymphocytes On the issue of peptide recognition in T cell development.T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis.Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.

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P2860

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.

http://www.wikidata.org/entity/Q46769839

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David Y Oh

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Nirav R Bhakta

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Richard S Lewis

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P2860

A single class II myosin modulates T cell motility and stopping, but not synapse formation

A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

The transcription factor NFAT4 is involved in the generation and survival of T cells

Calcium oscillations increase the efficiency and specificity of gene expression

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

Calcium signaling mechanisms in T lymphocytes.

Positive and negative selection of T cells.

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