Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment.
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Post-translational regulation of endothelial nitric oxide synthase in vascular endotheliumInactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimersBeta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzymeTRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress.Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.The NO cascade, eNOS location, and microvascular permeability.The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177.Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx.eNOS-beta-actin interaction contributes to increased peroxynitrite formation during hyperoxia in pulmonary artery endothelial cells and mouse lungs.Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation.Molecular regulation of NADPH oxidase 5 via the MAPK pathway.Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeabilityPKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins.eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels.Subcellular targeting and trafficking of nitric oxide synthases.Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase.Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.Life history of eNOS: partners and pathways.The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition.Endothelial nitric oxide (NO) and its pathophysiologic regulationInternalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules.Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS.Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction.Specificity in S-nitrosylation: a short-range mechanism for NO signaling?Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells.Regulation of eNOS enzyme activity by posttranslational modification.Preclinical anatomical, molecular, and functional imaging of the lung with multiple modalities.Mass spectrometric analysis of protein tyrosine nitration in aging and neurodegenerative diseases.The eNOS signalosome and its link to endothelial dysfunction.An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide.Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation.Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN.The Molecular Basis of Portal Hypertension.Nitric oxide and cancer.Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation.Mechanisms of vascular insulin resistance: a substitute Akt?Where is endothelial nitric oxide synthase more critical: plasma membrane or Golgi?The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction.Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis.
P2860
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P2860
Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Differences in eNOS activity b ...... the local calcium environment.
@en
Differences in eNOS activity b ...... the local calcium environment.
@nl
type
label
Differences in eNOS activity b ...... the local calcium environment.
@en
Differences in eNOS activity b ...... the local calcium environment.
@nl
prefLabel
Differences in eNOS activity b ...... the local calcium environment.
@en
Differences in eNOS activity b ...... the local calcium environment.
@nl
P2860
P356
P1476
Differences in eNOS activity b ...... the local calcium environment
@en
P2093
David Fulton
P2860
P304
P356
10.1074/JBC.M505968200
P407
P577
2005-10-28T00:00:00Z