Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesHuman but not mouse adipogenesis is critically dependent on LMO3Modulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modificationsContext Specific and Differential Gene Co-expression Networks via Bayesian BiclusteringA concerted kinase interplay identifies PPARgamma as a molecular target of ghrelin signaling in macrophages.The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.Endogenous ω-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in miceRasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat dietAltered microRNA expression in bovine subcutaneous and visceral adipose tissues from cattle under different diet.β-catenin directly sequesters adipocytic and insulin sensitizing activities but not osteoblastic activity of PPARγ2 in marrow mesenchymal stem cells.Green tea polyphenols reduced fat deposits in high fat-fed rats via erk1/2-PPARγ-adiponectin pathwayDifferential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptorElucidation of molecular mechanisms of physiological variations between bovine subcutaneous and visceral fat depots under different nutritional regimes.PPARγ: a circadian transcription factor in adipogenesis and osteogenesis.Obesity, metabolic syndrome, and adipocytesBeta-arrestin-1 protein represses diet-induced obesity.Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesityPPARgamma and MEK Interactions in CancerObesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistanceChanges in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selectionBidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.Regulation of PPARgamma function by TNF-alpha.Disabled-2 Determines Commitment of a Pre-adipocyte Population in Juvenile Mice.Posttranslational modifications of PPAR-gamma: fine-tuning the metabolic master regulator.Docking proteins.Molecular cross-regulation between PPAR-γ and other signaling pathways: implications for lung cancer therapy.Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside.Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.Effect of age on bovine subcutaneous fat proteome: molecular mechanisms of physiological variations during beef cattle growth.Challenges in Drug Discovery for Thiazolidinedione Substitute.Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events.Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation.FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes.PPARgamma and Agonists against Cancer: Rational Design of Complementation Treatments.The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain.Nck2, an unexpected regulator of adipogenesis.The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes.The anti-adipogenic effect of PGRN on porcine preadipocytes involves ERK1,2 mediated PPARγ phosphorylation.
P2860
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P2860
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@en
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@nl
type
label
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@en
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@nl
prefLabel
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@en
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation.
@nl
P2093
P356
P1433
P1476
Dok1 mediates high-fat diet-in ...... of PPAR-gamma phosphorylation
@en
P2093
Hiroshi Sakaue
Kazuo Takazawa
Kazutoshi Tobimatsu
Masato Kasuga
Mitchell A Lazar
Ryuji Hiramatsu
Takehiro Nakamura
Tetsuya Hosooka
Tetsuya Noguchi
P2888
P304
P356
10.1038/NM1706
P407
P577
2008-01-20T00:00:00Z