Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.
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The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanismBrain-Derived Neurotrophic Factor: Three Ligands, Many ActionsImmune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticityBDNF deregulation in Rett syndromeOverexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized ratsProteolysis of proBDNF is a key regulator in the formation of memoryHuntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and releasePrecursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingPhencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brainDisruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.BDNF-dependent consolidation of fear memories in the perirhinal cortex.Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice.Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression.Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes.BDNF Val66Met polymorphism and protein levels in amniotic fluidTheranostic Biomarkers for SchizophreniaBrain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway.Neurobiology of local and intercellular BDNF signaling.A single Aplysia neurotrophin mediates synaptic facilitation via differentially processed isoforms.Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.The p75 neurotrophin receptor is required for the major loss of sympathetic nerves from islets under autoimmune attackMethamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor.Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesisReduced levels of brain-derived neurotrophic factor contribute to synaptic imbalance during the critical period of respiratory development in rats.Brain-derived neurotrophic factor and the development of structural neuronal connectivity.Central and systemic responses to methionine-induced hyperhomocysteinemia in miceUnderstanding proneurotrophin actions: Recent advances and challenges.ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA.BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 miceBrief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 micep75 regulates Purkinje cell firing by modulating SK channel activity through Rac1.Abnormalities in the zinc-metalloprotease-BDNF axis may contribute to megalencephaly and cortical hyperconnectivity in young autism spectrum disorder patients.Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell culturesNew insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases.New insights in the biology of BDNF synthesis and release: implications in CNS functionMethamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus.Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI.Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition.CXCL8 protects human neurons from amyloid-β-induced neurotoxicity: relevance to Alzheimer's disease.GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels.
P2860
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P2860
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@en
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@nl
type
label
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@en
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@nl
prefLabel
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@en
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@nl
P2093
P356
P1433
P1476
Biosynthesis and processing of ...... nd secrete BDNF, not pro-BDNF.
@en
P2093
Johannes Klose
Martin Korte
Martin Polack
Roland Kolbeck
Stefanie Rauskolb
Tomoya Matsumoto
P2888
P304
P356
10.1038/NN2038
P407
P577
2008-01-20T00:00:00Z