Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.
about
Cellular senescence impact on immune cell fate and functionA natural genetic variant of granzyme B confers lethality to a common viral infectionGranzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisFailed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B.Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734Fas ligand and lytic granule differentially control cytotoxic dynamics of natural killer cell against cancer targetA functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.Human NK cells activated by EBV(+) lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells.Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors.Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.Immunity, Granzymes and Cell Killing
P2860
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P2860
Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Blocking granule-mediated deat ...... nhibition of caspase activity.
@en
Blocking granule-mediated deat ...... nhibition of caspase activity.
@nl
type
label
Blocking granule-mediated deat ...... nhibition of caspase activity.
@en
Blocking granule-mediated deat ...... nhibition of caspase activity.
@nl
prefLabel
Blocking granule-mediated deat ...... nhibition of caspase activity.
@en
Blocking granule-mediated deat ...... nhibition of caspase activity.
@nl
P2093
P2860
P50
P356
P1476
Blocking granule-mediated deat ...... inhibition of caspase activity
@en
P2093
C J P Clarke
K A Sedelies
N J Waterhouse
V R Sutton
P2860
P2888
P304
P356
10.1038/SJ.CDD.4402300
P50
P577
2008-01-18T00:00:00Z