Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.
about
Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology DomainProspective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasA k-nearest neighbor classification of hERG K(+) channel blockers.Future directions for drug transporter modelling.The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channelInteractions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and functionThe emerging role of antiarrhythmic compounds with atrial selectivity in the management of atrial fibrillation.Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets.Revealing the structural basis of action of hERG potassium channel activators and blockers.Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?hERG1 potassium channel in cancer cells: a tool to reprogram immortality.Development of Safe Drugs: The hERG Challenge.Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling.hERG ion channel pharmacology: cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.Lack of electrocardiographic effect of dexlansoprazole MR, a novel modified-release formulation of the proton pump inhibitor dexlansoprazole, in healthy participants.Binding modes of hERG blockers: an unsolved mystery in the drug design arena.Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.
P2860
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P2860
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@en
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@nl
type
label
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@en
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@nl
prefLabel
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@en
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@nl
P2093
P356
P1476
Drug binding interactions in t ...... ofilium and ibutilide analogs.
@en
P2093
Claire Wood
Derek Leishman
Joanne Leaney
John S Mitcheson
Marcel J de Groot
Matthew Perry
Michael J Sutcliffe
Phillip J Stansfeld
P304
P356
10.1124/MOL.105.016741
P577
2005-11-16T00:00:00Z