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Neuronal apoptosis: BH3-only proteins the real killers?Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons.AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMFRegulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells.Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability.TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.Excitotoxic injury to mitochondria isolated from cultured neurons.Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer.NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis.Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.A CRIS in the Desert: The Implementation of Pure at KAUST A Case Study in Information ExchangeGlutamate excitotoxicity and neuronal energy metabolismQuantitative analysis of membrane potentials
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Manus W. Ward
@ast
Manus W. Ward
@en
Manus W. Ward
@es
Manus W. Ward
@nl
Manus W. Ward
@sl
type
label
Manus W. Ward
@ast
Manus W. Ward
@en
Manus W. Ward
@es
Manus W. Ward
@nl
Manus W. Ward
@sl
prefLabel
Manus W. Ward
@ast
Manus W. Ward
@en
Manus W. Ward
@es
Manus W. Ward
@nl
Manus W. Ward
@sl
P106
P1153
7403168712
P31
P496
0000-0002-7085-9668