Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
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Chapter 14: Cancer genome analysisDNA sequencing of a cytogenetically normal acute myeloid leukaemia genomeActivating mutations in ALK provide a therapeutic target in neuroblastoma.The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis controlAneuploidy and improved growth are coincident but not causal in a yeast cancer model.Sequence and structure signatures of cancer mutation hotspots in protein kinasesRole of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53Functional characterization of human cancer-derived TRKB mutations.Cancer driver mutations in protein kinase genesEmerging FMS-like tyrosine kinase 3 inhibitors for the treatment of acute myelogenous leukemiaA small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.Rapid Identification of Therapeutic Targets in Hematologic Malignancies via Functional Genomics.Cancer gene discovery in mouse and man.Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.Our changing view of the genomic landscape of cancer.Molecular damage in cancer: an argument for mTOR-driven agingEnhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia.Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coinProfiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.Programmed genetic instability: a tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line.A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivityFunctional modules, mutational load and human genetic diseaseFrom cancer genomes to cancer models: bridging the gapsPhase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status.JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science.Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutantsIdentification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesWhole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors.Molecular diagnosis of leukemia.Deciphering oncogenic drivers: from single genes to integrated pathways.Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.Discovery and characterization of novel mutant FLT3 kinase inhibitors
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P2860
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Identification of driver and p ...... sessment of candidate alleles.
@en
Identification of driver and p ...... sessment of candidate alleles.
@nl
type
label
Identification of driver and p ...... sessment of candidate alleles.
@en
Identification of driver and p ...... sessment of candidate alleles.
@nl
prefLabel
Identification of driver and p ...... sessment of candidate alleles.
@en
Identification of driver and p ...... sessment of candidate alleles.
@nl
P2093
P50
P1433
P1476
Identification of driver and p ...... sessment of candidate alleles.
@en
P2093
Benjamin H Lee
Benjamin L Ebert
Claudia Scholl
D Gary Gilliland
James D Griffin
Jingrui Jiang
Marc Loriaux
Marcus M Schittenhelm
Michael W Deininger
Olivier A Bernard
P304
P356
10.1016/J.CCR.2007.11.005
P577
2007-12-01T00:00:00Z