Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
about
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseCrystal structures of human SIRT3 displaying substrate-induced conformational changesSirtuin functions and modulation: from chemistry to the clinicStructural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionThe Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)Application of the protein semisynthesis strategy to the generation of modified chromatinA continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.SIRT3 substrate specificity determined by peptide arrays and machine learning.Sirtuin chemical mechanismsThiomyristoyl peptides as cell-permeable Sirt6 inhibitors.Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.Sirtuin catalysis and regulationTechnologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides.Mechanism-based affinity capture of sirtuinsA mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)Novel sirtuin inhibitory warheads derived from the N(ε)-acetyl-lysine analog L-2-amino-7-carboxamidoheptanoic acid.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Novel thiourea-based sirtuin inhibitory warheads.A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolismMechanisms and molecular probes of sirtuins.Chemical mechanisms of histone lysine and arginine modificationsStructural basis for sirtuin function: what we know and what we don't.Small molecule SIRT1 activators for the treatment of aging and age-related diseases.Erasers of histone acetylation: the histone deacetylase enzymes.Sirtuin mechanism and inhibition: explored with N(ε)-acetyl-lysine analogs.Catalysis and mechanistic insights into sirtuin activation.An update on lysine deacylases targeting the expanding "acylome".New assays and approaches for discovery and design of Sirtuin modulators.Sirtuin inhibitors as anticancer agents.New Modalities for Challenging Targets in Drug Discovery.Development of substrate-derived mechanistic sirtuin inhibitors with potential anti-cancer activity.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.A chemical probe toolbox for dissecting the cancer epigenome.Chemical and structural biology of protein lysine deacetylasesThiosuccinyl peptides as Sirt5-specific inhibitorsMeasurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.Azalysine analogues as probes for protein lysine deacetylation and demethylation.
P2860
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P2860
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@en
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@nl
type
label
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@en
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@nl
prefLabel
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@en
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@nl
P356
P1433
P1476
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
@en
P2093
John M Denu
P304
14478-14486
P356
10.1021/BI7013294
P407
P50
P577
2007-11-21T00:00:00Z