Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.
about
An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitinationThe WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsThe MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokinesX-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalizationA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1PP4 is essential for germinal center formation and class switch recombination in miceDeciphering gene expression program of MAP3K1 in mouse eyelid morphogenesisMAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells.Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity.TNF and MAP kinase signalling pathways.Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated disruption of the CD40 ligand-induced activation of primary human B cells.Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and diseaseNovel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2).Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.Agonistic CD40 antibodies and cancer therapy.Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.Molecular mechanism and function of CD40/CD40L engagement in the immune system.How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?LTβR and CD40: working together in dendritic cells to optimize immune responses.Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.Signaling mechanisms regulating B-lymphocyte activation and tolerance.Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses.CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-Jun N terminal kinase activation independent from the interferon pathway.JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative ExpansionGlobal gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomasEssential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.Genetic insights into Map3k-dependent proliferative expansion of T cells.The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling.Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
P2860
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P2860
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Kinase MEKK1 is required for C ...... ation and antibody production.
@en
Kinase MEKK1 is required for C ...... ation and antibody production.
@nl
type
label
Kinase MEKK1 is required for C ...... ation and antibody production.
@en
Kinase MEKK1 is required for C ...... ation and antibody production.
@nl
prefLabel
Kinase MEKK1 is required for C ...... ation and antibody production.
@en
Kinase MEKK1 is required for C ...... ation and antibody production.
@nl
P2093
P356
P1433
P1476
Kinase MEKK1 is required for C ...... ation and antibody production.
@en
P2093
Amy Anzelon-Mills
Atsushi Matsuzawa
Dennis Otero
Edith Janssen
Ewen Gallagher
Ryan Holzer
Thomas Enzler
P356
10.1038/NI1421
P407
P577
2006-12-03T00:00:00Z