WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
about
Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modificationsTowards an understanding of kidney diseases associated with WT1 mutationsDeducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant miceEx vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signalsThe PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.A synthetic niche for nephron progenitor cellsGenome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory MechanismsConcurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cellsDifferential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulatorsFibroblast growth factor receptor signaling in kidney and lower urinary tract development.The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.Osr1 Interacts Synergistically with Wt1 to Regulate Kidney OrganogenesisTranscription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction.The Role of WT1 in Embryonic Development and Normal Organ Homeostasis.Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.Identifying Direct Downstream Targets: WT1 ChIP-Seq Analysis.Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.SOX2 suppresses the mobility of urothelial carcinoma by promoting the expression of S100A14.Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries.Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and -KTS isoforms-From initial observations to recent global genomic analyses.Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene Sox9 in murine embryonic gonads.Wilms' tumour 1 (WT1) in development, homeostasis and disease.Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease
P2860
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P2860
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
@wuu
2014年学术文章
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2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
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2014年學術文章
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2014年學術文章
@zh-hant
name
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@en
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@nl
type
label
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@en
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@nl
prefLabel
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@en
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@nl
P2093
P2860
P50
P356
P1476
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
@en
P2093
André W Brändli
Fabian A Buske
Fariba Jian Motamedi
M Rita Lecca
Michael Clarkson
Norbert Hübner
P2860
P2888
P356
10.1038/NCOMMS5444
P407
P577
2014-07-17T00:00:00Z