LPA1 receptor activation promotes renal interstitial fibrosis. - Wikidata - awgldk - TriplyDB

LPA1 receptor activation promotes renal interstitial fibrosis.

LPA1 receptor activation promotes renal interstitial fibrosis.

http://www.wikidata.org/entity/Q46899860

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Structural basis of substrate discrimination and integrin binding by autotaxin Lysophospholipids and their receptors in the central nervous system ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling Mechanisms of fibrosis: therapeutic translation for fibrotic disease International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.Role of LPA4/p2y9/GPR23 in negative regulation of cell motility Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers.MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy LPA receptor signaling: pharmacology, physiology, and pathophysiology.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Acute kidney injury: a springboard for progression in chronic kidney disease Lysophospholipid receptor nomenclature review: IUPHAR Review 8.A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model.Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts Aiming drug discovery at lysophosphatidic acid targets.New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive.Vascular involvement in systemic sclerosis (scleroderma).Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis.Insights into the pharmacological relevance of lysophospholipid receptors.H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury Chemical evolution of autotaxin inhibitors Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis.LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.Lysophosphatidic acid and renal fibrosis.Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now?Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis.Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.Lysophosphatidic acid-1-receptor targeting agents for fibrosis.Anti-fibrosis therapy and diabetic nephropathy.Pharmacological strategies to spare normal tissues from radiation damage: useless or overlooked therapeutics?Targeted therapies for systemic sclerosis.New renal drug development to face chronic renal disease.Lysophosphatidic acid as a lipid mediator with multiple biological actions.Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

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P2860

LPA1 receptor activation promotes renal interstitial fibrosis.

http://www.wikidata.org/entity/Q46899860

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

@zh-my

2007年学术文章

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2007年學術文章

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2007年學術文章

@zh-hant

name

LPA1 receptor activation promotes renal interstitial fibrosis.

@en

LPA1 receptor activation promotes renal interstitial fibrosis.

@nl

type

label

LPA1 receptor activation promotes renal interstitial fibrosis.

@en

LPA1 receptor activation promotes renal interstitial fibrosis.

@nl

prefLabel

LPA1 receptor activation promotes renal interstitial fibrosis.

@en

LPA1 receptor activation promotes renal interstitial fibrosis.

@nl

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Journal of the American Society of Nephrology

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LPA1 receptor activation promotes renal interstitial fibrosis.

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P2093

Charlotte Guigné

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Denis Calise

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Eric Neau

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Jean-Philippe Pradère

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Jean-Sébastien Saulnier-Blache

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Jerold Chun

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Philippe Valet

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Sandra Grès

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3110-3118

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scholarly article

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10.1681/ASN.2007020196

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12

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18

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Joost P Schanstra

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2007-11-14T00:00:00Z

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18003779

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