Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.
about
A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPThe auto-inhibitory role of the EPAC hinge helix as mapped by NMRExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsSubstrate-specific reorganization of the conformational ensemble of CSK implicates novel modes of kinase functionRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)Dynamically driven ligand selectivity in cyclic nucleotide binding domains.Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channelsThe projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation FactorsStructure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Solution NMR Spectroscopy for the Study of Enzyme Allostery.EPAC proteins transduce diverse cellular actions of cAMP.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.cAMP-dependent allostery and dynamics in Epac: an NMR view.Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activityIntracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
P2860
Q27684011-A11AEBA1-1993-4A8B-8104-0519BE96328EQ28485307-D26A66D8-5B81-4453-9DBD-4C039600A431Q28608179-A3567A21-C239-4905-ADBF-D65939BCBFB9Q30009998-CBF31D94-E943-4AC2-B66C-312048600166Q30405298-B046044A-6ECC-427F-B21A-8689FB1A51E7Q34211343-A89D7E4B-2011-499F-956B-F9FCA27A4617Q34978413-1F7BFF0C-1E27-4BB3-8F06-09A93383B0BAQ35018179-5B25868F-A748-4F53-86B2-8EC37A65DB34Q35743330-F8E677DB-CFCB-46C3-B2CA-2A5F1CE6AB53Q35838268-BC9CD7CC-1929-4C40-9F39-BDB73F47E96BQ36624204-98013769-4AF7-4DE6-9028-89FEFCE11D29Q37076848-AC0CB3FF-EFB1-4741-8B2C-ACADA02B5162Q37390882-1A875283-A0D7-47DD-8BEA-FBAAEC4D1C5FQ37632467-8E632D45-DB3A-449E-A986-977FA9448FFBQ37977182-672DF843-3DD1-4510-A63C-8B15C0965FC0Q40391237-A015D78D-3E09-48AB-80C5-B4CE30739C05Q42232851-12CEF723-06F7-44E1-AC58-9DD1CF8FDAC8Q42580094-E2853EE1-65C6-4B1B-83F7-C1805297AD06Q52656382-FE02AB35-42CE-48C2-A7CB-9505C82063EB
P2860
Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@en
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@nl
type
label
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@en
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@nl
prefLabel
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@en
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@nl
P2093
P50
P356
P1476
Understanding cAMP-dependent a ...... its apo and cAMP-bound states.
@en
P2093
Giuseppe Melacini
Soumita SilDas
Steven A Fotheringham
P304
14482-14492
P356
10.1021/JA0753703
P407
P577
2007-10-31T00:00:00Z