JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
about
Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cellsIn silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human HepatocytesLigand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs.Co-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression.Venetoclax (ABT-199) Might Act as a Perpetrator in Pharmacokinetic Drug-Drug Interactions.Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways.Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives.Impact of enzalutamide and its main metabolite N-desmethyl enzalutamide on pharmacokinetically important drug metabolizing enzymes and drug transporters.Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.Effects of adrenolytic mitotane on drug elimination pathways assessed in vitro.Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.2,3',4,4',5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway.Interaction potential of the multitargeted receptor tyrosine kinase inhibitor dovitinib with drug transporters and drug metabolising enzymes assessed in vitro.Role of c-Jun-N-terminal kinase in pregnane X receptor-mediated induction of human cytochrome P4503A4 in vitro.CYP gene family variants as potential protective factors in drug addiction in Han Chinese.Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
P2860
Q28533661-83E39458-F389-42EF-9D7B-887153F7B505Q34360082-DA36ED7B-A933-497F-B756-E7F6A55D3220Q36006457-2608CCB3-8926-452A-A3D5-0D02D74A6330Q36181367-1353A58A-59D6-4CAD-AC9A-38C94182C6C0Q36313788-955A16EE-B3E0-4FD8-97BA-314EF9FCDE53Q36735325-308EB2B8-15D4-4C90-8DD1-52292FDDF1E0Q36815972-AC6FE93D-3134-434A-8E59-15236C9E6EE0Q37137662-F12007C8-1282-4593-BAE7-4D9130B5EEF0Q37279436-2331AFB9-A243-4B21-934D-8B593BE3E742Q37756178-5AC19C7E-B7AF-4B57-A6E1-B4C220FD5879Q38588143-49BBE342-0DBB-4CAD-BF80-534287420A44Q38597025-0C471D7C-E349-4EA2-8340-DE39A4D54DCDQ38845179-6FF79A3D-E04A-4043-B2F6-1256F0A9D1E3Q38925278-57E39333-526B-4EC6-B7AD-A4183CF8C68DQ42219264-C08E13C7-F2BF-4992-A75E-D7AE4A9BC5C4Q42700239-222739F3-C791-413B-BE5C-90FDAA2F55DAQ43084566-3856BA61-F578-416B-AFDD-47CBD8794F89Q50027324-D8D30DCB-1D9D-4934-8F34-12180F13708CQ51306296-8C3A64B6-FA77-444B-9618-A029B16DF956Q58735041-306C9C1F-AB29-46DC-AB23-90092AD51053
P2860
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@en
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@nl
type
label
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@en
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@nl
prefLabel
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@en
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@nl
P2093
P50
P1476
JNK inhibitor SP600125 is a pa ...... in primary human hepatocytes.
@en
P2093
Jiri Ehrmann
Karel Lemr
Lucie Svecova
Patrick Maurel
Pavla Henklova
Petr Bednar
Petra Jancova
Radim Vrzal
Roman Havlik
P304
P356
10.1016/J.BCP.2007.09.013
P407
P577
2007-09-16T00:00:00Z