Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease. - Wikidata - awgldk - TriplyDB

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

http://www.wikidata.org/entity/Q46966608

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Translatability scoring in drug development: eight case studies Biological markers of amyloid beta-related mechanisms in Alzheimer's disease Notch signaling as a novel regulator of metabolism Amyloid-β and APP deficiencies cause severe cerebrovascular defects: important work for an old villain Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and Challenges New computer-aided diagnosis of dementia using positron emission tomography: brain regional sensitivity-mapping method Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.Targeting Abeta and tau in Alzheimer's disease, an early interim report Update on the pharmacological treatment of Alzheimer's disease The secretases: enzymes with therapeutic potential in Alzheimer disease.Progress in Alzheimer's disease.Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound Current treatment and recent clinical research in Alzheimer's disease Current and emerging drug treatment options for Alzheimer's disease: a systematic review.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.RBPJ is a novel target for rhabdomyosarcoma therapy.A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease Disease-modifying treatments for Alzheimer's disease.Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production.Neuronal death in Alzheimer's disease and therapeutic opportunities.An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD).Effects of recombinant erythropoietin on breast cancer-initiating cells.Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice.Tarenflurbil: mechanisms and myths.Therapeutic options in Alzheimer's disease.NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease.100 years and counting: prospects for defeating Alzheimer's disease An update on pharmacological approaches to neurodegenerative diseases.In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

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P2860

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

http://www.wikidata.org/entity/Q46966608

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Alzheimer's disease