Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. - Wikidata - awgldk - TriplyDB

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

http://www.wikidata.org/entity/Q33531734

about

The notch ligand JAGGED1 as a target for anti-tumor therapy Notch signaling: its roles and therapeutic potential in hematological malignancies Targeting Notch to overcome radiation resistance Impact of notch signaling on inflammatory responses in cardiovascular disorders Notch receptor-ligand binding and activation: insights from molecular studies Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia In vitro models of cancer stem cells and clinical applications Notch ligand endocytosis: mechanistic basis of signaling activity Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor.Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia Mammary development and breast cancer: the role of stem cells FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors Notch inhibitors for cancer treatment.Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Differential involvement of Hedgehog signaling in butterfly wing and eyespot development.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABL A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer.Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Notch signaling in skeletal stem cells.Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations.Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Notch regulation of tumor angiogenesis.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.New pathways and mechanisms regulating and responding to Delta-like ligand 4-Notch signalling in tumour angiogenesis.

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P2860

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

http://www.wikidata.org/entity/Q33531734

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@ast

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@en

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@nl

type

label

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@ast

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@en

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@nl

prefLabel

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@ast

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@en

Characterization of Notch1 ant ...... and mutated Notch1 receptors.

@nl

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JOURNAL.PONE.0009094

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Characterization of Notch1 ant ...... and mutated Notch1 receptors.

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Andrew J Bett

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Beth A Arnold

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Elizabeth Thoryk

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Frederic Baleydier

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Fubao Wang

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Giovanni Roti

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Hans E Huber

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Hongfang Wang

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Hui Wang

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Janet E Lineberger

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P2860

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

Dll4, a novel Notch ligand expressed in arterial endothelium

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

Nuclear signalling by tumour-associated antigen EpCAM

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1

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Kimberly Stegmaier

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2010-02-08T00:00:00Z

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41453507

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20161710

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