Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
about
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activityPivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetateDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolCrystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implicationsStructural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2Allosteric coupling in pyruvate dehydrogenase kinase 2Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cellsDichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor.Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
P2860
Q24317423-8487C8D8-9F51-4BF4-A667-ECC667DAB967Q24336339-CA796172-2E9C-4B73-99C6-495D6862495EQ24336876-9414F52B-8C99-4ED0-9DFB-4A6E00A7A09CQ24681121-564A028F-56A7-4DB8-8D73-9AC2A245A0AAQ27650224-B12B1D51-1359-47FF-932F-6FD2F994778AQ28287166-26AFD720-215A-4324-8AAD-2BB3AAD73ADDQ34548748-27C84864-21BD-4AD9-94D8-0A0650911C56Q36269713-E302D7B2-5B23-4EBF-B02A-C4EC67E03AACQ37644942-0B9547FE-1254-4F20-AB0F-FBB7261B349CQ42413782-AB120EA4-589D-46D9-9D37-D838B76C37DEQ42821704-24D55B96-35EF-4114-90E1-53D8AD4889B3Q47615969-AAB4144E-06B5-4801-9090-7EA2CBCA0576
P2860
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@en
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@nl
type
label
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@en
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@nl
prefLabel
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@en
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@nl
P2093
P2860
P356
P1476
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
@en
P2093
Liangyan Hu
Thomas E Roche
Yasuaki Hiromasa
P2860
P304
12568-12579
P356
10.1074/JBC.M513514200
P407
P577
2006-03-03T00:00:00Z